Description of tablets "Concor"
"Concor" is a medication that is used to treat low blood pressure, sore throat, and also to normalize heart rhythm. The active ingredient is 2 compounds:
- Bisoprolol fumarate.
- Bisoprolol hemifumarate.
Available in the form of tablets, each of which contains 5 or 10 mg of the main component. Dispensed in pharmacies only with a prescription. Can be stored under normal conditions (at a temperature not exceeding 30 degrees) for the total shelf life (5 years from the date of production).
Release form and composition
Concor blood pressure tablets are available in several dosages - 5 and 10 mg of the active ingredient (bisoprolol fumarate). The light yellow, biconvex, heart-shaped tablets are scored on both sides for easy halving.
In addition to the main substance, the composition also includes auxiliary substances. These are corn starch, colloidal silicon dioxide, magnesium stearate, anhydrous calcium hydrogen phosphate, MCC. The shell consists of hypromellose, macrogol 400, dimethicone 100, yellow and red dyes iron oxide, titanium dioxide.
The drug Concor Cor has a reduced dose of the active component - 2.5 mg. This allows the drug to be prescribed to people for whom standard Concor is too strong, for example, with low blood pressure.
The main active ingredient of the drug is bisoprolol. Its main purpose is to protect the heart from the negative effects of catecholamines, including adrenaline. This allows you to effectively normalize blood pressure, restore optimal heart rate, reduce the risk of heart attack and other complications of hypertension. If beta blockers of previous generations in tablets and capsules affected the skeletal muscles, bronchi and pancreas, then Concor does not have such disadvantages, which makes it extremely safe.
How do beta blockers work for hypertension?
Contraindications
In some cases, taking the drug is prohibited:
- exacerbation of heart failure;
- a sharp decrease in pressure;
- cardiogenic shock;
- acidosis;
- intolerance to individual components, allergic reactions;
- bronchial asthma;
- blockade (sinoatrial and AV type).
The product is indicated for use only in adult patients. Children under the age of 17 inclusive are prohibited from using Concor. In this case, the pediatrician must develop a different course of therapy.
Attention!
Taking the product during pregnancy and breastfeeding (at any stage) is allowed, but with caution. There are no reported cases of complications, but therapy should be agreed with a doctor.
Side effects
Side effects are rare, but they are not excluded:
- cramps, muscle weakness;
- bronchial asthma (exacerbation);
- sleep disorders;
- depressive states;
- headaches;
- dizziness;
- rarely – loss of consciousness;
- conjunctivitis;
- nausea;
- diarrhea;
- problems with potency;
- allergic reactions (itching, rashes, rhinitis of allergic origin).
Adverse reactions to the drug
Although the medicine is usually well tolerated, in some cases adverse reactions to the components of the tablets occur. This:
- weakness, increased fatigue;
- sleep problems;
- depressive states;
- short-term memory lapses;
- hearing, vision, taste impairments;
- dermatological reactions;
- stomach cramps;
- intestinal disorders;
- circulatory disorders;
- heart failure.
It is worth considering that side effects are temporary and appear at the initial stage of treatment, completely disappearing after 2 weeks of therapy. This is evidenced by numerous reviews from doctors and their patients.
Instructions for use of "Concor" tablets
The drug is started with a small dose - 5 mg per day. If necessary, it can be increased to 10 mg. If the patient suffers from high blood pressure or angina pectoris, a maximum amount of 20 mg per day can be taken. In case of chronic heart failure (without acute periods) – 10 mg.
"Concor" is taken as a primary or additional means. It is often used in conjunction with blockers of diuretics, cardiac glycosides, and ACE inhibitors. The course of treatment is long until the desired effect is achieved. Specific terms are not specified in the instructions, so the patient should consult a doctor before starting treatment.
Important!
During treatment, alcohol intake is completely contraindicated. If possible, you should reduce or quit smoking. In consultation with your doctor, you need to follow a certain diet.
Indications for taking the drug
Concor, which is often called “Concord”, is prescribed for a number of disorders in the functioning of the cardiovascular system. This:
- arterial hypertension;
- stable angina;
- cardiac ischemia;
- chronic cardiac failure.
Concor is also taken for low blood pressure accompanied by rapid heartbeat. The dosage is selected strictly individually. For example, it is believed that 2.5 mg of bisoprolol cannot lower blood pressure, but copes with other duties perfectly.
If a patient is diagnosed with hypertension, he may be recommended another medicine - Concor AM. This drug for high blood pressure contains 2 active ingredients at once - amplodipine and bisoprolol in an optimal ratio.
Concor AM tablets, in addition to bisoprolol (5 or 10 mg), include another active ingredient - amplodipine (5 or 10 mg)
Cases of overdose
In case of overdose, there is a severe drop in blood pressure and other dangerous consequences:
- exacerbation of heart failure;
- hypoglycemia;
- bronchospasm;
- AV block;
- bradycardia.
Treatment is symptomatic, depending on the nature of the exacerbation. For example, to relieve the symptoms of bradycardia, atropine is administered, and in case of glycemia, a glucose solution is administered. If bronchospasm is observed, it is treated with Aminophylline. In case of a serious condition, it is necessary to call emergency assistance as quickly as possible.
Analogs
Concor helps to effectively reduce blood pressure and has virtually no side effects. However, the price of the drug is not affordable for everyone. Selecting a high-quality alternative treatment that has a similar effect on the body will help you cope with the situation. Among the most popular of them are the following:
- Bisoprolol,
- Biol,
- Niperten,
- Coronal,
- Bisogamma and others.
A doctor who will take into account the characteristics of each medication will help you choose a substitute.
Drug interactions
The drug is not recommended to be combined with medications such as Bisopropol. It leads to a decrease in the conductivity and contractility of the heart, which can lead to bradycardia. In turn, this will lead to vasodilation.
With caution, Concor is combined with drugs based on amiodarone and parasympathomimetic agents. If you use hypoglycemic drugs, their effect will increase. If used together with cardiac glycosides, symptoms of bradycardia will appear.
Parallel use of adrenergic agonists leads to an increase in blood pressure. If you use Mefloquine at the same time, this will again cause symptoms of bradycardia.
Concor - treatment of arterial hypertension and heart rhythm disturbances
Concor is an effective drug for the treatment of diseases of the cardiovascular system.
Treatment of diseases of the cardiovascular system is a big problem. For many conditions, precise selection of drug dosages is required. Therefore, a drug that is convenient for the patient to prescribe and take is very important. Such a drug includes Concor or bisoprolol.
There are receptors in the heart and blood vessels that, when influenced, cause various effects, such as increased heart rate, increased or decreased blood pressure, and others. Concor is a selective beta1-blocker. This type of receptor is located in the heart. If this type of receptor is stimulated, heart rate increases, and the force of contraction also increases, which leads to an increase in the need for nutrients and oxygen in various tissues, in particular the myocardium. In addition, blood pressure increases.
With heart disease, patients experience an increase in blood pressure and an increase in heart rate. A special feature of Concor is its selective blockade of this type of receptor. That is, the drug acts exclusively on beta 1 receptors, without affecting other receptors.
The drug is available in two dosages: 5 and 10 mg. Bisoprolol is synthesized in the form of tablets; there is also an intravenous form, but it is used exclusively in a hospital to obtain a quick effect.
By blocking beta 1 receptors, Concor has:
- hypotensive effect - reduces blood pressure,
- antiarrhythmic - eliminates certain types of rhythm disturbances,
- antianginal - the main mechanism is associated with a decrease in the myocardium's need for oxygen, which is accompanied by improved blood supply, dilation of the blood vessels of the heart, this also leads to a decrease in pain in the heart area.
This drug, unlike others in this group, does not have its own sympathomimetic activity. This means that it only blocks the receptors without causing them to be stimulated at the same time. In addition, it slightly stimulates beta 2 adrenergic receptors without causing significant effects. Beta 2 receptors are located mainly in the bronchi, and when stimulated, they can affect the bronchi, causing many side effects.
Already 3 hours after absorption, the drug has its maximum effect. In some conditions, it is enough to prescribe the drug once, and the effect lasts throughout the day. When analyzing blood pressure after administration of the drug, the greatest effect is observed at the end of the second week of taking the drug.
90% of the active substance of the drug is absorbed into the blood after oral administration. Food and water do not affect the amount of drug absorption.
The main metabolic pathway of concor is oxidative. All metabolites formed in this process are excreted through the kidneys. At the same time, the formed substances are inactive.
Various experiments have shown that CYP3A4 (most of the drug) and CYP2D6 are involved in inactivation.
Concor is prescribed for high blood pressure, myocardial ischemia (stable angina), as well as long-term heart failure. Since this drug is prescribed only by a doctor, he takes into account the patient’s contraindications.
The main contraindications for use are decompensated conditions of cardiovascular diseases: acute heart failure, cardiogenic shock, severe life-threatening arrhythmias (AV block, sick sinus syndrome, sinoatrial block). In addition, given the possible effect on other adrenergic receptors in severe bronchial asthma, Concor is also contraindicated.
In addition to contraindications, it is necessary to remember that Concor can affect many chronic diseases, such as diabetes mellitus, kidney and liver dysfunction, psoriasis, structural disorders of the heart (cardiomyopathy, heart defects).
When taking Concor during pregnancy, you must remember that it affects the blood supply to the placenta, which can cause various pathologies in the fetus. Concor should not be taken while breastfeeding.
Taking the drug can cause various side effects. The most common effects include dizziness, fatigue, and hearing problems. The most pronounced effects are on the functioning of the heart and blood vessels: a decrease in heart rate. If the patient had signs of chronic heart failure, then its manifestations may worsen. In addition, vomiting, nausea, and muscle weakness may occur.
Considering that the treatment of cardiovascular diseases is complex and the patient needs to take a fairly large number of medications, the attending physician must know with which medications Concor can be taken. Particular caution should be taken when taking the medicine with all other antiarrhythmics, medications that affect the functioning of the heart and blood vessels, since their effect can be additive and lead to worsening arrhythmias and an excessive decrease in blood pressure. Also, we must not forget about abrupt withdrawal of the drug. In this case, severe rebound arterial hypotension may occur.
The drug is usually taken in the morning or once during the day. The dosage of the drug is determined only by the attending physician, who will prescribe the medicine based on clinical data and laboratory tests. Most often, the drug is prescribed with 5 mg 1 time. Next, you need to assess the level of blood pressure reduction and, if necessary, increase the dosage. For concomitant diseases of the heart and blood vessels, the dose of the drug can be further reduced to 1.25 mg with a subsequent increase in dosage. Usually the dose is increased once a week.
In some cases, it will be necessary to adjust the doses of other medications. Most often, concor is prescribed for a long period.
If the dose of the drug is chosen incorrectly, signs of overdose may occur. Usually they will manifest themselves as disturbances in the functioning of the heart.
In this case, treatment will be carried out symptomatically, that is, depending on the individual symptoms. If a sharp and marked decrease in heart rate is observed, atropine may be required. With a pronounced decrease in blood pressure, the administration of various solutions or drugs that constrict blood vessels is required.
Only a doctor can change the dosage, since if the dosage is incorrect, the condition may worsen.
Thus, Concor is the optimal remedy in the fight against various diseases of the heart and blood vessels, having a selective effect on their receptors.
concorrection of arterial hypertension and treatment of cardiac arrhythmias
special instructions
In some cases, there are no direct contraindications to the use of Concor. However, it should be taken with caution if you have the following disorders:
- following a strict diet (for example, after surgery, to correct weight);
- psoriasis;
- diabetes mellitus (if its course is accompanied by hypoglycemia);
- Prinzmetal's angina;
- AV block (first degree).
