More than once at an appointment I came across a situation where a patient without any obvious cardiovascular pathology prescribed cardiomagnyl (or thromboASS, cardio aspirin, etc.), being sure that absolutely everyone at his age (that is, “after 45 -50 years"), this is exactly the kind of prevention of cardiovascular diseases that is needed. After all, the neighbor also drinks, they say on TV that it’s necessary, and so on...
Is it really necessary?
The fact is that modern recommendations for the treatment of cardiovascular diseases (CVD) speak of the need for lifelong use of aspirin by those people who have already suffered any cardiovascular events. These include heart attack, stroke, transient ischemic attacks. As for the use of aspirin by people who do not have a history of any cardiovascular diseases, including those listed above, today the routine administration of aspirin (or other antithrombotic drugs) to such patients is not recommended due to the lack of evidence supporting First of all, the safety of such prophylaxis in this category of patients.
The most common side effect when taking aspirin is a negative effect on the gastric mucosa. Also, with its long-term use, the risk of bleeding of various localizations (gastrointestinal, hemorrhoidal, nasal, etc.) increases, and this fact cannot be neglected, because in certain situations such bleeding can become life-threatening.
In this regard, before prescribing aspirin to a patient, the doctor must assess the benefits and risks of taking it. In patients who have had a heart attack or stroke, the benefits of prophylactic aspirin have been shown to outweigh the possible risk of bleeding and are therefore recommended. And the role of aspirin in people who have no history of either one has not been fully studied. The scientific data that we have today indicate that there is no clear benefit from such prevention and, at the same time, an increased risk of bleeding of various locations. However, the issue remains poorly understood; large studies are ongoing, and we are waiting for their results.
As for patients of older age groups who have any risk factors for the development of cardiovascular diseases (arterial hypertension, high blood cholesterol, etc.), patients with diabetes mellitus, the situation is approximately the same: it has not yet been revealed that The benefit of taking aspirin outweighs the risk of bleeding in such patients, and therefore its use cannot be recommended routinely.
Differences between the drugs "Cardiomagnyl" and "Thrombo ACC"
More detailed information about each drug will help you understand the differences between these medications. Next, we will consider in detail the composition and indications of the drugs. The mechanism of action of active components on the human body is also very important.
In what situations are they prescribed?
The clinical purposes of these drugs are the same. Some experts prescribe them alternately. This avoids becoming addicted to one particular medicine. These medications are prescribed to people with cardiovascular diseases. They are also used for preventive purposes of myocardial infarction and cardiac ischemia.
The active components of medications ensure normal blood flow to the affected organs and block the adverse reactions of other drugs (birth control pills).
The doctor may prescribe these medications to patients with angina pectoris, pain in the chest area and inflammation in the veins. The drugs have a positive effect on the functioning of the heart muscle after surgery.
In cardiology, Cardiomagnyl and Thrombo ACC are prescribed in the following cases:
- - heart failure;
- – thrombosis of the lower extremities;
- – poor blood circulation in the arteries of the brain;
- – damage to the heart vessels;
- – rehabilitation after aortic bypass surgery;
- – when blood clots occur in the veins;
- – migraine attacks;
- – insufficient blood supply to the brain;
- – for preventive purposes (myocardial infarction, ischemic disease).
In addition, medications are prescribed in the following cases:
- – joint pathology;
- – inflammation of ligaments and intervertebral discs;
- – to facilitate the delivery of the base drug (improves blood circulation in the affected area).
Differences in composition
The basic active component of these drugs is aspirin. This element copes well with inflammation, stabilizes body temperature, and eliminates pain in the head and muscles.
Thanks to the active substance, blood cells do not stick together (thrombosis), and blood clots do not form. Taking medications reduces the possible development of cardiac necrosis in case of insufficient blood supply to the heart muscle. In addition, medications are prescribed to patients with cardiovascular diseases.
The main disadvantage of aspirin is severe irritation of the gastric mucosa. Long-term use provokes the formation of bleeding ulcers on the walls of the stomach. If you take the drug after surgery, hemorrhage may occur.
Additional components of "Trombo ACC":
- – milk sugar;
- - silica;
- - potato starch.
The main component (acetylsalicylic acid) is coated. The tablet dissolves in the duodenum, not in the stomach. Thanks to this, the gastric mucosa remains unharmed.
Additional components of "Cardiomagnyl":
- – talc;
- – macrogol;
- - corn starch;
- - potato starch;
- – methyloxypropylcellulose;
- – magnesium hydroxide;
- – magnesium stearate.
Based on this information, we can conclude that Cardiomagnyl is safer for the stomach rather than Thrombo ACC. In addition, it contains components that have a positive effect on the digestive system.
Differences in dosing
Medicines are available in tablet form.
- The dosage of “Trombo ACC” film-coated tablets is 50 milligrams and 100 milligrams. They have a round shape, convexities on both sides.
- The dosage of Cardiomagnyl is 75 milligrams and 150 milligrams. Tablets can be oval or heart-shaped.
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The choice of the appropriate medicine, determining the dosage and drawing up the treatment regimen should be done by the doctor.
Cost difference
The drug "Cardiomagnyl" is significantly more expensive than "Thrombo ACC". However, it should be borne in mind that its dosage is also less.
Table of approximate prices for Cardiomagnyl and Thrombo ACC:
| Tromboass | Cardiomagnyl | ||
| 50 mg | 100 mg | 75 mg | 150 mg |
| 28 pcs. – 47 rub. | 28 pcs. – 60 rub. | 30 pcs. – 132 rub. | 30 pcs. – 134 rub. |
| 100 pieces. – 141 rub. | 100 pieces. – 165 rub. | 100 pieces. – 218 rub. | 100 pieces. – 275 rub. |
Description of Trombital
The tablets are produced in Russia; they contain 2 main components - acetylsalicylic acid and magnesium hydroxide. They have an antithrombotic and antiaggregation effect. A favorable result is achieved by influencing platelets. The medicine inhibits the process of thromboxane synthesis, as a result of which their activity in connecting with the walls of blood vessels decreases. The adhesion to each other is also inhibited, which prevents the formation of blood clots. The result is noticeable within a week of use.
Properties of Trombital:
- Acetylsalicylic acid has a positive effect on the cardiovascular system. Treatment with the drug reduces mortality in myocardial infarction.
- Prothrombin time increases, the intensity of prothrombin production in the liver and the concentration of coagulation factors decreases.
- Additional qualities: has antipyretic, anti-inflammatory, analgesic effect. Enhances the excretion of uric acid.
The disadvantage of Trombital is its adverse effect on the mucous membrane of the gastrointestinal tract.
To prevent the risk of complications, a second substance was added to the composition - magnesium hydroxide.
Main indications for taking tablets:
- prevention of pathologies of the heart and arteries;
- unstable angina;
- prevention of blood clots;
- decreased likelihood of recurrent myocardial infarction;
- prevention of thromboembolism after capillary surgery.
You should not take Trombital under 18 years of age, during pregnancy, lactation, with heart failure, intestinal or cerebral hemorrhages, sensitivity to constituent substances, liver or kidney disorders, or bronchial asthma.
Admission restrictions
Both drugs have the same contraindications.
Among them:
- – individual intolerance to one of the components of the drug;
- – presence of allergies;
- – the body’s tendency to bleed;
- – pregnancy and lactation;
- – severe heart disease;
- – acute form of gastritis;
- – kidney diseases;
- – stomach and duodenal ulcers.
Prescribed with caution to children and elderly patients. Patients with gout, respiratory tract and liver diseases are treated under medical supervision.
When Cardiomagnyl is contraindicated
The prohibition on the use of the drug in therapy includes:
- childhood;
- individual intolerance to any of the components;
- exacerbation of peptic ulcer;
- severe renal failure;
- history of angioedema or other allergic reactions to aspirin;
- decompensation of heart failure;
- bronchial asthma;
- vitamin K deficiency, impaired hematopoietic function.
Side effects
The drugs cause the same side effects:
- – painful sensations in the abdominal area;
- – gusts of vomiting;
- – heartburn;
- – poor blood clotting;
- – dizziness;
- – apathy;
- – anemia;
- – rash on the skin;
- – itching;
- – deterioration of hearing abilities;
- – inflammation of the nasal mucosa.
In particularly difficult situations, the following may arise:
- – stomach or intestinal ulcer;
- – bleeding and hematomas in the gastrointestinal tract;
- – inflammatory process in the esophagus;
- – liver dysfunction;
- - anaphylactic shock.
In rare cases, negative manifestations may occur. However, it is not difficult to eliminate them. Most patients tolerate treatment with these medications well.
Exceeding the prescribed dose may cause poisoning. Signs of overdose appear when the dose exceeds 150 milligrams per 1 kilogram of the patient’s body weight.
Manifestations of overdose:
- – apathy;
- – severe weakness throughout the body;
- – attacks of nausea;
- - vomit;
- – increased sweating;
- – depression;
- – low blood pressure;
- - noise in ears.
In case of overdose, it is necessary to urgently rinse the stomach or take any sorbent. It could be activated carbon. It is not recommended to combine drugs with alcoholic beverages. This can lead to unforeseen complications.
What are the dangers of an overdose of Cardiomagnyl?
The maximum daily dose of the drug is 150 mg. Exceeding it will lead to serious intoxication of the body:
- impaired coordination of movements;
- sweating;
- hearing loss, dizziness;
- lowering blood pressure;
- nausea and vomiting.
Acute poisoning is fraught with vascular collapse, loss of consciousness, respiratory disorders, and liver failure. Assistance in case of an overdose of Cardiomagnyl after gastric lavage should be provided by medical specialists.
Difference in advantages and disadvantages
"Cardiomagnyl" and "Trombo ACC" are identical in their mechanism of operation and prescriptions. The main difference is the composition of the drugs.
Advantages and disadvantages of Cardiomagnyl
The product does not provoke the occurrence of pathologies in the digestive tract. This is ensured by magnesium compounds. One tablet contains a fairly large concentration of the active ingredient.
In addition, the dosage of the drug is 1.5 times higher than that of Trombo ACC. Thus, even with an increased dosage, it is very convenient to use tablets.
One of the main disadvantages is the high price. In addition, patients with kidney disease should use the tablets with extreme caution.
Advantages and disadvantages of Trombo ACC
The tablets can be purchased at an affordable price. In addition, patients note good tolerability of the drug.
Among the shortcomings, it is worth highlighting the lack of substances that could protect the gastric mucosa from negative factors.
Based on this, we can say for sure that Cardiomagnyl is suitable for patients with diseases of the gastrointestinal tract. Thrombo ACC is best taken by patients with renal failure.
Characteristics of thromboassa
Compound
Thromboass consists of acetylsalicylic acid. The tablets contain 50 and 100 mg of the active substance and are coated, which is resistant to gastric juice and dissolves in the duodenum. Thus, acetylsalicylic acid does not irritate the gastric mucosa.
Reception possible
Taking thromboassa is possible in case of renal failure.
The drug can be taken by pregnant women in the first and second trimesters.
Incompatibility
The following should not be taken with thromboass:
- hypoglycemic and diuretic agents;
- glucocorticoids;
- anticoagulants.
Not recommended
Thromboass is not recommended for patients with digestive tract problems or nursing mothers.
Possible consequences
After taking the drug, there is a possibility of menstrual irregularities, dizziness, iron deficiency anemia, and bronchospasms.
In what cases is it prescribed
Thromboass is prescribed:
- for heart attacks;
- with thrombosis;
- to improve cerebral circulation.
Which medicine is best for varicose veins?
Both drugs are prescribed for varicose veins. However, doctors choose the appropriate option depending on the specifics of the disease.
Varicose veins can develop on any veins. For example, if this disease affects the veins of the rectum, hemorrhoids will occur. The development of varicose veins can be caused by blood that is too thick. Moving through the veins, it greatly stretches them.
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To treat this pathology, the doctor may prescribe Cardiomagnyl or Thrombo ACC. In terms of dosage, the first drug is more effective. It contains a higher concentration of acetylsalicylic acid. You only need to take 100-200 mg of medication per day. Thrombo ACC contains a much smaller amount of aspirin.
However, when choosing between these drugs, the therapist takes into account the characteristics of the patient’s body. If you have high acidity, Trombo ACC is suitable, and if you have stomach diseases, it is better to take Cardiomagnyl.
Which drug thins the blood better?
Due to the anticoagulant effects of aspirin, both drugs increase blood flow. In this case, you can take the drugs for a fairly long period. The drug regimen is formed taking into account the concentration of aspirin, the presence of protective effects for the stomach and the price for the full course of treatment.
If you look at it from a price point of view, Trombo ACC is cheaper. However, you need to take more of it due to the low concentration of the active substance. The price of Cardiomagnyl is quite high, but it also contains more aspirin. ASA not only thins the blood, but also affects its clotting.
Comparison of the effectiveness of Cardiomagnyl and Thrombus ACC
The effectiveness of Cardiomagnyl is quite similar to ACC Thrombus - this means that the ability of the drug substance to provide the maximum possible effect is similar.
For example, if the therapeutic effect of Cardiomagnyl is more pronounced, then using Thrombus ACC, even in large doses, will not achieve this effect.
Also, the speed of therapy - an indicator of the speed of therapeutic action - is approximately the same for Cardiomagnyl and Thrombus ACC. And bioavailability, that is, the amount of a drug reaching its site of action in the body, is similar. The higher the bioavailability, the less it will be lost during absorption and use by the body.
Which drug is safer for the stomach?
Thrombo ACC tablets dissolve not in the stomach, but in the intestines. Thus, the gastrointestinal tract is not susceptible to the negative effects of aspirin. This drug is excellent for patients with gastric and duodenal ulcers.
Cardiomagnyl contains magnesium hydroxide, which reduces acidity levels and has a positive effect on peristalsis. It is recommended to take the medicine with plenty of water. This will help reduce the negative impact on the digestive system.
Such actions will help you be on the safe side, even if the drug does not have protective functions for the stomach. You can use low-fat milk or alkaline water instead of regular water.
Can pregnant and breastfeeding women take the drugs?
Some pregnant women need blood thinning medications. Is it possible to use Cardiomagnyl and Thrombo ACC? Which of these drugs is best suited during pregnancy and lactation?
Such diseases must be treated. Otherwise, the pathology can provoke disturbances in the development of the fetus. These drugs can be prescribed during pregnancy and lactation.
However, certain rules for their use must be observed:
- – the medicine should not be taken on an empty stomach, although this is indicated in the instructions;
- – the doctor prescribes the minimum dosage;
- – therapy is carried out only under the supervision of a doctor;
- – it is better not to carry out treatment in the first and second trimester.
You should also follow additional recommendations. If a pregnant patient needs to take these medications, she should drink plenty of fluids. This will help remove toxic substances from the body, and also soften the negative effects of the chemical components of the drug.
Concomitant use of drugs
It is not recommended to take Cardiomagnyl and Thrombo ACC at the same time. If you look at the active component, indications and side effects, these drugs are completely different. They differ not only in composition, but also in dosage.
When choosing a drug, first of all, the general condition of the patient and the degree of development of the disease are taken into account. In addition, you need to pay attention to the woman’s age and individual tolerance to aspirin.
It is forbidden to use and select the dosage yourself. Even for the purpose of prevention, the drug must be prescribed by the attending physician (therapist, surgeon or cardiologist).
Effective drug analogues
The following drugs are analogues of Cardiomagnyl, Thrombo Ass, Trombital. Many of them have different active components, but the properties and purposes are identical. Of course, the price category of the drugs also differs.
Table with effective medications:
| A drug | Active substance | Manufacturer | Price in rubles |
| Aspirin Cardio | acetylsalicylic acid | Germany | From 80 |
| Thrombogard | acetylsalicylic acid | Bulgaria | From 50 |
| Thrombopol | acetylsalicylic acid | Poland | From 39.50 |
| Asparkam | potassium and magnesium aspartate | Russia | From 48 |
| Acecardole | acetylsalicylic acid | Russia | From 25 |
| Panangin | potassium and magnesium aspartate | Hungary | From 121 |
| Fasostabil | acetylsalicylic acid + magnesium hydroxide | Russia | From 165 |
| Clopidogrel | clopidogrel | Russia | From 400-670 |
| Brilinta | ticagrelor | Sweden | From 2500 |
| Trental | pentoxifylline | India | From 429 |
| Aspecard | acetylsalicylic acid | Belarus | From 27 |
After a thorough analysis of blood thinning drugs with different active substances, it is clear that in this field there is an extensive list of medications that are indicated for patients with different disorders.
Acecardol is an antiplatelet agent
One tablet of Acecardol contains 50/100 mg of the main element - acetylsalicylic acid. Excipients: magnesium stearate, talc, povidone, starch. High doses of the drug exhibit an antipyretic and analgesic effect. The component is completely absorbed into the digestive canal and is only partially metabolized during absorption. The price of Acecardol is cheap and amounts to 25 rubles. for 50 mg.
What is Acecardol used for:
- unstable angina;
- prevention of recurrent myocardial infarction;
- prevention of deep vein thrombosis;
- warning of pulmonary embolism;
- disorder of the blood supply to the brain to prevent ischemic stroke;
- after invasive procedures and vascular operations to prevent thromboembolism (stenting, bypass surgery).
The tablets are contraindicated for people with erosive and ulcerative pathologies of the gastrointestinal tract, hemorrhagic diathesis, hemorrhages from the duodenum, and stomach. Bronchial asthma, provoked by the use of salicylates, becomes a limitation. It is also prohibited in case of heart failure, liver failure, or during lactation. Compatibility with methotrexate at a dose of more than 15 mg per 7 days is not acceptable. The use of Acecardol is not allowed for patients with gout, nasal polyposis, or drug allergies. Acetylsalicylic acid is often the cause of bleeding during operations.
Fasostabil - analogue of Cardiomagnyl, Trombital
The main substance of Fazostabil is acetylsalicylic acid, magnesium hydroxide. In essence, the mechanism of action of ASA is the irreversible inhibition of cyclooxygenase, as a result of which thromboxane synthesis is suppressed and platelet aggregation is inhibited. The second component in the composition exhibits an antacid effect and protects the mucous membrane of the digestive tract from the negative effects of ASA.
What does Fazostabil help with:
- prevention of secondary myocardial infarction, thrombosis of blood arteries;
- unstable angina;
- prevention of thromboembolism after capillary operations;
- primary prevention of heart pathologies.
How much to take, what is the dosage:
- In order to prevent a recurrent heart attack, only 1 tablet is required. per day in the amount of 75-150 mg;
- angina pectoris - 1 tablet. in the morning or evening;
- prevention of thromboembolism also involves 1 tablet. per day.
When Fazostabil is used simultaneously with valproic acid, narcotic analgesics, and metatrexate, their interaction increases, which increases the likelihood of toxicity. Adverse reactions are possible when used together with thrombolytic and hypoglycemic drugs, heparin and other antiplatelet medications. Alcohol should not be taken along with Fazostabil; it reduces the effect of the medication and can lead to complications. The price of the drug in Russian pharmacies is from 165 rubles. per package.
Advice from cardiologists, which drug is better?
So, Cardiomagnyl or Thrombo ACC, what is the advice of cardiologists? Doctors unanimously leave only positive reviews about these drugs. In cardiology, both Cardiomagnyl and Thrombo ACC are actively used.
Compared to traditional acetylsalicylic acid, they provide a mild effect. Most doctors believe that the main difference between them is the price.
Litovchenko E. A., cardiologist
The antiplatelet medicine "Trombo ACC" perfectly thins the blood in the veins and prevents their blockage. The active component is in a special film. The tablet dissolves not in the stomach, but in the intestines, so the gastrointestinal mucosa cannot be damaged by the effects of aspirin. The drug is quite reliable, well tolerated and practically does not cause adverse reactions.
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In my opinion, the drug “Cardiomagnyl” copes well with diseases of the heart and blood vessels. I would also like to note the convenient dosage of the medicine. I prescribe it to patients with gastrointestinal diseases. Magnesium hydroxide helps neutralize gastric juice, which is secreted in large quantities in patients with stomach pathologies.
Both drugs are effective against thrombosis. In the presence of this disease, the drugs act exactly the same.
Kravets L. G., cardiologist
Clinical studies show that Cardiomagnyl effectively thins the blood. In this case, it is better not to use analogues. The main advantage of the drug is the presence of an additional component - magnesium hydroxide, which protects the walls of the stomach from the effects of aspirin. This drug is excellent for patients with gastrointestinal diseases.
For the prevention of coronary disease and heart attack, Thrombo ACC is more suitable. However, both drugs are effective for venous embolism and thrombophlebitis. Adverse reactions compared to pure aspirin are minor. My patients tolerate it better than Cardiomagnyl. However, this directly depends on the individual characteristics of the organism.
It is important to note that cardiologists at public hospitals prefer to prescribe Thrombo ACC and Aspirin Cardio, while in private clinics they prefer more solid drugs.
Doctors' opinions on the drug "Thrombo ACC"
Trukhanova E. N., therapist, Moscow
I prescribe Thrombo ACC to my patients quite often. One of the advantages of antiplatelet medicine is its affordable cost. The tablets are film-coated, which protects the gastric mucosa from the negative effects of acetylsalicylic acid.
In addition, "Thrombo ACC" can be taken for quite a long time. However, this cannot be done without consulting a specialist. Otherwise, adverse reactions may occur.
Sokolovskaya E. G., hematologist, Volgograd
This drug is an antiplatelet agent. Thanks to a special coating that dissolves only in the intestines, the medicine does not have a negative effect on the stomach. Their patients are prescribed short courses of therapy. Long-term treatment is possible if thrombophilia develops.
I would like to note the high efficiency and reliability of the drug. Thrombo ACC score – 5 points!
In what cases should you take Cardiomagnyl?
The medicine is prescribed to prevent complications in the following pathologies:
- risk of developing myocardial infarction;
- condition after a heart attack;
- chronic cardiac ischemia;
- diabetes;
- hypertonic disease;
- atherosclerosis, high cholesterol;
- risk of thrombosis with varicose veins.
Cardiomagnyl is unable to replace drugs for lowering blood pressure, does not regulate heart rhythm and has no effect on the general course of the disease. Its function is to prevent the development of thrombosis. The drug is also not used as a source of magnesium.
Patients' opinions about the drug "Thrombo ACC"
Elena Alexandrovna, Vologda
Taking the drug helped thin the blood and bring all indicators back to normal. I started taking it immediately after menopause. I would like to note that my condition improved quite quickly. I recommend Thrombo ACC for the prevention of ischemia and heart attack.
Larisa Grigorievna, Ekaterinburg
High quality product at an affordable price. In my case, the deciding factor was the price. Since I am a diabetic, the doctor prescribed me to take Thrombo ACC on a regular basis. The medicine is an excellent prevention of heart attack. The latest test results indicate the high effectiveness of the drug.
Doctors' opinions on the drug "Cardiomagnyl"
Karpova L. G., therapist
People over 40 years old often suffer from diseases of the cardiovascular system. You can reduce the risk of developing such pathologies with the help of Cardiomagnyl tablets (75 mg). Almost all of my patients tolerate this medicine well.
There are no adverse reactions. For a fairly low price you can buy this high-quality drug. Cardiomagnyl should not be taken without a prescription from the attending physician (cardiologist, therapist).
Sidorov S. P., vascular surgeon
My patients, who are over 50 years old, suffer from vascular diseases. I prescribe Cardiomagnyl, dosage 75 mg. Take after meals 1 time per day. A very effective medicine that reduces the risks of thrombosis, stroke and heart attack. In vascular surgery, this drug is simply irreplaceable.
Patients' opinions about the drug "Cardiomagnyl"
Nikolay, 54 years old
The attending physician prescribed blood thinners. After the stroke, I took Aspirin (0.5 tablets). The list also included “Aspirin Cardio”, “Thrombo ACC” and “Cardiomagnyl”. It was the last drug that I liked the most. Thanks to the presence of magnesium, the medicine protects the stomach and heart. Now the blood is not viscous, and the heart is working just fine.
Svetlana, 45 years old
My mother suffers from high blood pressure. Due to shortness of breath, she could not even climb to the 2nd floor. The attending physician prescribed her Cardiomagnyl. We bought a package of this drug for 300 rubles. For retirees, of course, it’s expensive, but it’s worth it.
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