There are many drugs that are used to normalize blood pressure. Physiotens is one of them. Next, you will learn how Physiotens works, how to use it correctly, what contraindications and side effects it has.
Hypertension is a pathology that is gaining more and more momentum every day. The reasons for this factor are different sources - these are stressful conditions, unhealthy diet, intense rhythm of life. This factor cannot be ignored. After all, hypertension can be life-threatening and cause death due to severe complications. In pharmacies you can find various pills to alleviate the patient’s condition. Physiotens tablets have an effective effect, reducing blood pressure to normal levels if you choose the right dosage for the patient. Next, we will study their instructions in detail.
Physiotens tablets 0.2, 0.4 mg: instructions for use, dosages for hypertensive crisis
Drugs in dosages of 0.2; 0.4 milligrams are produced in tablet form. They are convenient to use. The main component of Physiotens is a component such as moxonidine. Its quantity is determined by the dosage of the pharmaceutical product, respectively: 0.2-0.3 mg. The pills also contain other auxiliary components (talc, macrogol, titanium dioxide, etc.). The dosage form is dispensed according to a doctor's prescription; it is recommended to store the pills for no more than two to three years, this is directly dependent on the packaging material.
Physiotens from pressure
The tablets are taken orally, it does not matter - before or after meals. Dosages are adjusted by a specialist doctor individually for each patient. Initially, it is recommended to start using pills with a low dosage of moxonidine - 0.2 mg , and then increase the amount of the drug if necessary. You are allowed to drink no more than 0.4 mg of Physiotens at a time, and no more than 0.6 mg per day . This dosage is divided into two doses. In case of kidney disease, the dosage should not be exceeded - 0.4 mg per day; in such cases, you can drink 0.2 mg once.
IMPORTANT : Be sure to remember that you should not exceed the recommended dose of the drug, which is 0.6 milligrams per day. And even during serious attacks, you should not take two 0.3 tablets at a time; divide them into two doses.
Pharmacokinetics
Suction
Absorption - 90%. Cmax in blood plasma (after taking a tablet containing 0.2 mg moxonidine) is 1.4–3 ng/ml and is achieved after 60 minutes. Bioavailability - 88% (food intake does not affect pharmacokinetics).
Distribution
Volume of distribution - 1.4–3 l/kg. Penetrates through the BBB. Plasma protein binding - 7.2%.
Metabolism
Main metabolites: 4,5-dihydromoxonidine and guanidine derivatives.
Removal
T1/2 of moxonidine and metabolites is 2.5 and 5 hours, respectively. Within 24 hours, more than 90% of moxonidine is excreted by the kidneys, approximately 78% unchanged and 13% as a dehydrogenated derivative. Less than 1% is excreted in feces. Does not accumulate with prolonged use.
Pharmacokinetics in old age
Age-related changes in pharmacokinetics are observed, probably associated with slightly higher bioavailability and/or reduced metabolic activity. However, these changes are not clinically significant.
Pharmacokinetics in renal failure
Moxonidine excretion is significantly correlated with creatinine clearance. In patients with moderate renal failure (Cl creatinine in the range of 30–60 ml/min), equilibrium plasma concentrations and final T1/2 are approximately 2 and 1.5 times higher than in patients with arterial hypertension with normal renal function (Cl creatinine >90 ml/min). In patients with severe renal failure (Cl creatinine <30 ml/min), steady-state plasma concentrations and final T1/2 are 3 times higher than in individuals with normal renal function. The administration of multiple doses of the drug does not lead to accumulation in the body of patients with moderate renal failure. At later stages, in patients with extremely severe renal failure (Cl creatinine <10 ml/min) on hemodialysis, steady-state plasma concentrations and final T1/2 are 6 and 4 times higher, respectively, than in patients with normal renal function. In patients with impaired renal function, the dosage should be adjusted individually. Moxonidine is excreted to a small extent during hemodialysis.
How to take Physiotens correctly: under the tongue or with water?
When taking Physiotens, it is recommended to monitor your blood pressure and measure your pulse. To eliminate the manifestations of the disease, beta-adrenergic receptor blockers are taken along with Physiotens. If the patient needs to stop taking Physiotens, then first stop taking the blockers, and then the drug itself.
Rules for taking Phytosiotens
According to the instructions, the pills should be taken with water, but if a more effective effect of the tablets is required, then it is better to dissolve the tablet under the tongue. The active substances will penetrate the bloodstream, which significantly accelerates the normalization of blood pressure in patients. Use this method of taking the drug when a person’s blood pressure is too high.
IMPORTANT : Physiotens can be taken regardless of meal time. The required level of the main substance of the drug is achieved when only seven percent of moxonidine binds to plasma protein molecules. The highest level of the chemical component is recorded after 1.5-2 hours. The medicine comes out through the kidneys.
Physiotens: contraindications, side effects
Each pharmaceutical drug has its own advantages and contraindications; it is these contraindications that patients should pay attention to when choosing this or that drug. It is better not to use Physiotens in patients of the following categories:
- for patients under 18 years of age
- women in an interesting position and breastfeeding
- with bradycardia, if the pulse is less than fifty beats
- the patient has a disease in the form of heart failure in all forms of its manifestation
- for kidney pathologies
- when you are allergic to a medicine.
The official instructions say that Physiotens should not be given to teenagers under 18 years of age, but sometimes doctors lower this threshold, recommending taking the pills as early as 16 years of age. It is prescribed to patients if they have allergic reactions to the actions of other pills.
Can pregnant women drink Physiotens?
There is another list of contraindications to the use of tablets on an ongoing basis. But you can take Physiotens once. These include:
- Problems with lactose absorption, glucose malabsorption.
- Liver failure, various other organ pathologies, since the drug has a negative effect on the liver.
- Raynaud's disease, Parkinson's disease, epilepsy.
It is recommended to use the medicine with caution or once and for depression. Doctors do not advise patients with low weight to take pills.
How long can you take Physiotens without a break? Can you drink it on an ongoing basis?
Physiotens, as already mentioned, should be used by patients in small dosages. Otherwise, various side effects may occur. You will need to strictly monitor your pill intake and evaluate your condition, especially with long courses of taking the medication. You can take Physiotens for a long time, but on the condition that you measure your pulse and blood pressure several times daily.
The drug is used if the patient has type 2 or 3 hypertension; before use, consult your doctor about the dosage of the drug. The cardiologist must prescribe a comprehensive treatment regimen. Hypertension cannot be treated with Physiotens alone. A specialist doctor should also stop taking pills. This will take two weeks; you will again need to monitor your pulse and blood pressure.
special instructions
If it is necessary to cancel simultaneously taken beta-blockers and Physiotens, first cancel the beta-blockers and only after a few days - Physiotens®. During treatment, regular monitoring of blood pressure, heart rate, and ECG is necessary. You should stop taking Physiotens gradually. Patients with rare hereditary conditions of galactose intolerance, lactase deficiency or glucose-galactose malabsorption should not take this drug.
There is no data on the adverse effects of moxonidine on the ability to drive a car or operate machinery. There are reports of drowsiness and dizziness during treatment with moxonidine. This should be taken into account when performing the above steps.
Physiotens: overdose
The dosages of the drug have already been discussed, but unfortunately there are cases when even 0.4 mg causes an overdose. Much depends on the individual characteristics of the human body. It is a pity that there is no antidote to eliminate the symptoms of overdose. In case of overdose, if necessary, doctors prescribe Dopamine and Atropine.
Side effects of tablets
If you take Physiotens in large dosages, suppression of the nervous system may occur, which will cause increased drowsiness, weakness in muscle tissue, and increased glucose in the bloodstream. There may even be a drop in blood pressure, a feeling of dry mouth, and pain in the stomach. To alleviate the patient’s condition in this case, it is necessary to take appropriate measures:
- give the patient still water, not just once, but drink in small portions, as often as possible
- for severe symptoms of bradycardia, use Atropine
- if the pressure is too low, then give a Dopamine injection.
In some cases, patients from an overdose of Physiotens lose consciousness, feel nausea, diarrhea appears, and darken their vision. There are also skin rashes due to allergies, itching, and insomnia.
Physiotens: is it possible to split the tablet?
Most often, the tablet is split to get a smaller dosage or to save money. After all, a drug with a higher dosage, if used in half a tablet, will be cheaper than buying the required dosage. Physiotens can be divided in half.
During the research, scientists found that there were no problems with dividing blood pressure medications. This was established after a survey of 1618 patients. Only 4 percent of respondents said that the effect of taking half a tablet reduced the quality of their condition.
Operating principle
Physiotens is an original drug manufactured by Abbott Products, located in the United States. This is a powerful, innovative drug, the main ingredient of which is moxonidine. The medication does not belong to the first group of drugs that have a positive effect on the body, gradually normalizing high blood pressure. However, there is a certain category of patients for whom this medicine is the drug of choice. This is explained not only by a pronounced hypotensive effect, but also by a strong influence on the metabolic process. A large number of clinical studies have shown that the active substance of the drug can prevent the development of insulin resistance. It can also quickly normalize the metabolic processes occurring in the body and eliminate any disturbances.
When using a drug called Physiotens, patients experience a dual mechanism of action. It provides not only short-term (usually through its effect on the sympathetic centers of the brain), but also long-term control of blood pressure by suppressing the release of renin. This is an enzyme that regulates high blood pressure. While taking the medication, the excretory function of the urinary system, in particular the kidneys, significantly improves. In real clinical practice, a medicine called Physiotens is often used as part of combination therapy.
Moxonidine is the active component of the drug, which differs significantly from classical drugs in that it acts for a long time over several hours (6-12 hours).
As for the features of the action, Physiotens has a strong stimulating effect on imidazoline receptors, which are located in the medulla oblongata. They play an important role in the central regulation of blood pressure. Modulate the activity of the sympatho-adrenal system. These receptors are also responsible for regulating the production of pancreatic hormones. The medication in question and all its analogues have therapeutic effects such as:
- Reduced hyperactivity of the sympathetic nervous system.
- Increased sensitivity of peripheral tissues to insulin.
- Significant improvement in fat metabolism indicators.
- Minimizing the concentration of glucose and leptin, a hormone in adipose tissue that is responsible for energy metabolism.
The drug significantly reduces the content of renin, aldosterone and angiotensin II in the blood plasma. These effects are extremely important for individuals who suffer from surges in blood pressure. It should be noted that a gradual decrease in the activity of the renin-angiotensin-aldosterone system can prevent the development and progression of all kinds of structural changes in the left ventricle of the heart muscle, as well as arteries, veins and capillaries.
In the course of research, while taking Physiotens, results were obtained that indicate a significant improvement in the diastolic function of the left ventricle of the heart muscle. If the patient took the medication for a long time, it was possible to reduce the increase in volume (hypertrophy) of the left ventricle.
Another interesting feature of the drug was discovered - if the initial blood pressure is very high, then it decreases more effectively than with a slight deviation from the norm. It is because of this that the possibility of eliminating the hypertensive crisis was considered.
Undesirable side effects such as dry mucous membranes and strong sedation are practically not found with the drug in question. This helps improve the tolerability of the medication.
Physiotens or Moxonidine or Capoten: which is better, more effective?
It is impossible to say which drug is better for a particular patient. After all, people have different perceptions of different types of tablets. For some, Physiotens is not suitable at all, and for others, Capoten is not suitable. But if we judge the effectiveness of the drugs in general, then Physiotens and Moxonidine still have a better chance of success. The effect of using these drugs is stronger than that of Capoten. In addition to lowering blood pressure, the patient’s headache also stops hurting and his condition normalizes for a long time.
Capoten is a remedy that reduces blood pressure within 20-25 minutes, but its effectiveness lasts only six hours in a row. Therefore, hypertensive patients should always have Capoten in their first aid kit.
Kapoten - instructions for use
Capoten is suitable for patients with type 2 hypertension. It gently reduces the load on the heart and regulates the synthesis reaction in the adrenal glands. Moxidin and Physiotens are drugs with a similar active ingredient, so the tablets have the same effect.
The principle of action of Moxonidine
IMPORTANT : You cannot use blood pressure medications haphazardly and uncontrollably. This threatens irreparable harm to the patient’s body and worsening the condition. And if you decide to use the pills without consulting a doctor, then read the instructions carefully, pay attention to the rules of administration and contraindications.
PHYSIOTENS
Hypertension and excess weight: risk factors requiring a special therapeutic approach
Risk factors that significantly influence the development of cardiac diseases are quite well known today. Thus, the main factors determining the sharp increase in the risk of deaths include increased blood pressure and obesity. With the advent of new scientific data, approaches to their prevention and treatment are changing, and new medical and surgical methods are emerging to level out their impact. In particular, a symposium organized by the successful and actively developing pharmaceutical company Solway Pharma . The symposium was held in Moscow on October 12, 2006 as part of the Russian National Congress of Cardiologists. The theme of the symposium: “Hypertension and excess weight: risk factors that require a special therapeutic approach.” Opening the symposium, the chairman, Professor I.E. Chazova noted that all over the world every year there are more and more patients with arterial hypertension and most of them are overweight. In changed living conditions, the problem of obesity is high, and hypertension is inextricably linked with obesity, which determines the need for a special therapeutic approach to such patients.
The first report of the symposium, “Obesity, hypertension, insulin resistance. Blast wave effect or wave of explosions? , presented by Professor O.P. Shevchenko. At the beginning of the speech, the speaker recalled the well-known joke that everything good in this life is either illegal, immoral, or leads to obesity. In medicine, the problem of obesity today is moving to the forefront due to the progression of physical inactivity and excess calorie intake in society. One of the striking consequences of obesity is the development of arterial hypertension (AH). It is observed in 80% of cases. The risk scale with increasing BMI is also indicative: with a BMI of 25 kg/m 2, the risk of death increases by only 10% (i.e., equal to 1.1 compared to BMI 20-24). With a BMI of 35, the risk doubles, and with a BMI of 40 it is 2.5. It is also interesting that a BMI below 20 is associated with a slight increase in the risk of death (by 10-20%).
Obesity affects the condition of the vast majority of organs and systems. However, the cardiovascular system is considered the most sensitive today. Thus, in obese individuals, blood volume always increases due to Na retention, and the load on the heart increases due to an increase in cardiac output. The second component of the load is an increase in peripheral resistance, mainly due to an increase in vascular tone and hyperplasia of smooth muscle cells. Why does obesity have such an impact on heart function? Recently, numerous data have appeared indicating the active role of adipose tissue in metabolism due to the production of a huge number of compounds:
- Vasoactive (angiotensinogen, plasminogen activator inhibitor, tissue factor)
- Metabolically active: leptin, ghrelin, adiponectin, insulin antagonists, TNF-alpha, IL-6, resistin, as well as glucocorticoids and sex hormones.
As body weight increases, the production of these substances increases. The most well-known example of a “fat hormone” is leptin. Its blood level increases in proportion to the degree of obesity. It enhances thermogenesis by activating the sympathetic nervous system. Activation of the SNS, in turn, is explained by the direct activating effect of leptin on the ventromedial and dorsomedial nuclei of the hypothalamus. This is one of the main mechanisms of increased blood pressure in obesity. As for adiponectin, its concentration is the inverse of body fat content, and its effects are as follows:
- enhances the production of insulin and insulin-like growth factor
- activates PPAR receptors, which are also affected by fibrates, thereby increasing the level of adiponectin in the blood.
- suppresses TNF-alpha
- Acts on Nuclear Factor Kappa-B (involved in the pathogenesis of atherosclerosis)
Adiponectin suppresses atherogenesis because it is in a competitive relationship with TNF-alpha, and also reduces the effect of epidermal growth factor (HB - EGF). As a result, the formation of foam cells is suppressed, the action of adhesion molecules and blood clot formation is suppressed, and inflammation is reduced. Lack of adiponectin due to obesity contributes to the development of metabolic syndrome, which, in turn, leads to atherogenesis, the development of insulin resistance and type 2 diabetes, and persistent arterial hypertension. In particular, the connection with normalization of blood pressure is explained by increased NO production in the presence of adiponectin.
The development of insulin resistance is associated with many hereditary and acquired factors. However, it is known that with the development of insulin resistance, blood pressure increases. A possible mechanism is associated with blocking vasodilation under the influence of insulin against the background of activation of the sympathoadrenal system (SAS). The connection between insulin resistance (IR) and dyslipidemia is also interesting. Obstruction of insulin penetration into fat cells leads to an increase in the release of free fatty acids. This, in turn, leads to a shift in lipid metabolism towards an increase in VLDL, LDL, cholesterol, and TG. Dyslipidemia, in turn, increases atherogenesis. The combination of IR and hypertension increases the risk of damage to the atherosclerotic plaque, and therefore increases the risk of thrombosis. To summarize, we can draw the following conclusions:
- hypoadiponectinemia is an important risk factor for ischemic heart disease and cerebral stroke
- the cause of hypoadiponectinemia is obesity (mainly abdominal)
- hypoadiponectinemia increases inflammation, activates atherogenesis and increases the risk of thrombosis
- hypoadiponectinemia contributes to insulin resistance
- hypoadiponectinemia worsens the prognosis of coronary artery disease.
How to reduce IR, lower blood pressure, reduce atherogenesis and the risk of cardiovascular events? It is known that different groups of drugs have different effects on insulin resistance:
| Aggravate: | Do not affect: | Improve: |
| — Thiazide diuretics — Non-selective beta-blockers | — ACE inhibitors — Calcium antagonists — AT-1 receptor blockers — Alpha adrenergic blockers | Moxonidine (Physiotens) - imidozoline receptor agonist |
At the conclusion of his speech, Professor Shevchenko O.P. I noticed that today there is only one drug that reduces insulin resistance - Physiotens , the action of which is aimed at the nuclei of the brain, which leads to adequate restoration of the baroreflex.
Continuing the theme of the symposium, Professor I.E. spoke. Chazov with a report: “What conclusions of the ALMAZ study are of interest to a practicing physician?” . She noted that insulin resistance is closely related to abdominal obesity, which actually leads to decreased sensitivity to insulin. Subsequently, long-term hyperinsulinemia leads to the development of hypertension with type 2 diabetes. The relationship between hypertension and insulin resistance is more complex. In some cases, hypertension preceded diabetes, but the reasons for the formation of insulin resistance in hypertension are not yet clear enough.
Foreign studies show that the level of immunoreactive insulin and the insulin-glucose ratio in normotensive patients with a family history of hypertension is higher than in patients with high blood pressure, but without such a history. Russian observations in 60% of patients with hypertension without metabolic disorders also show the presence of insulin resistance. Therefore, not only patients with metabolic syndrome, in whom insulin resistance precedes an increase in blood pressure, should be carefully examined and observed. It is obvious that impaired glucose tolerance is the same unfavorable factor for vascular complications as, for example, the presence of diabetes. This has been proven in numerous studies. The incidence of coronary artery disease and strokes depends on the severity of carbohydrate metabolism disorders. Type 2 diabetes. Severe disturbances of carbohydrate metabolism in diabetes are associated with a very high risk of cardiovascular complications, morbidity and mortality. Consequently, insulin resistance is the main target of therapy in the treatment of patients with metabolic syndrome. Therefore, drugs that affect insulin resistance must have their own characteristics. It is necessary to take into account the effect of a particular drug on carbohydrate metabolism, even if there are no pronounced metabolic disorders.
What drugs are used to treat hypertension: diuretics, aldosterone antagonists, beta-blockers, calcium antagonists, ACE inhibitors, angiotensin receptor blockers, alpha-blockers and imidozoline receptor agonists. Imidazoline receptor agonists are a new class of antihypertensive drugs. VNOK experts included them in the class of recommended drugs for the treatment of hypertension, especially in the presence of diabetes and metabolic syndrome. One of the most famous drugs is moxonidine or Physiotens . A peculiarity of the drug’s action is the activation of type 1 imidazoline receptors in the midbrain. Against the background of activation of imidazoline receptors, a decrease in sympathetic activity appears, which leads to a decrease in blood pressure. A decrease in SNS activation also leads to a decrease in fat hydrolysis, a decrease in the content of free fatty acids, and an increase in glucose metabolism. All this leads to increased insulin sensitivity, decreased triglyceride levels, increased HDL cholesterol and decreased levels of tissue plasminogen activator inhibitor type 1. Thus, it becomes possible to effectively influence the pathogenetic links of the metabolic syndrome.
At one time, animal studies showed that Physiotens (moxonidine) can enhance the utilization of glucose, reduce the concentration of insulin in plasma, and reduce body weight. Clinical studies have fully confirmed these effects. The double-blind, placebo-controlled ALMAZ study showed that Physiotens reduced fasting glucose levels and reduced patients' weight. Physiotens increased the rate of glucose utilization and reduced insulin resistance. A comparison of the effectiveness of Physiotens and amlodipine showed the same antihypertensive effect, but Physiotens significantly improved carbohydrate metabolism.
And here is a study led by Academician Almazov. Physiotens was prescribed to patients with hypertension . A decrease in insulin resistance has been shown. The ALMAZ study confirmed the effect of moxonidine on insulin sensitivity. The effect of moxonidine and metformin on glycemic control in patients with excess weight, mild hypertension, decreased insulin sensitivity and impaired glucose tolerance was assessed. The study lasted 3.5 months. Fasting glucose levels on metformin and physiotensa (moxonidine). With moxonidine, fasting glucose levels decreased less pronounced than with metformin, and this is understandable. But Physiotens has a normalizing effect, so its effects are neutral in patients with normal glucose levels. During treatment, insulin levels decreased, while metformin had no effect on it. Metformin was more active in reducing glucose levels. But over time, body mass index also decreased significantly with moxonidine, as with metformin. The effect is probably due to the fact that everything in the metabolic syndrome is very connected: obesity, insulin resistance, hypertension, dyslipidemia - all these components of the symptom complex are mutually determined, reinforce and complement each other.
What findings are important for our clinical practice? Metabolic syndrome is extremely common. Insulin resistance is present in most patients with hypertension. And accordingly, drugs that specifically affect insulin sensitivity should be actively used in practice.
The final report of the symposium, “Are there any special considerations when choosing antihypertensive drugs in the treatment of arterial hypertension in overweight patients?” presented by Professor V.I. Podzolkov. At the beginning of the speech, a video based on films and cartoons dedicated to the problems of obesity was shown. At the end of the viewing, it was noted that, unfortunately, today there is the concept of an “obesity epidemic.” This indicates the enormous prevalence of overweight and related diseases. When we talk about metabolic syndrome (MS), we put central obesity first. The main criterion for MS is the waist – more than 94 cm in men and 80 cm in women. Everything else is a consequence of having such a waist. At the biochemical level, the events are based on dyslipidemia and insulin resistance. Excess weight gives a sharp increase in risks. The higher the weight gain in adulthood, the higher the risk of developing type 2 diabetes. The incidence of strokes in male doctors: with increasing BMI, the incidence of cases increases significantly. MS pathologically affects all organs and systems. We must not forget about the sharp increase in the risk of cancer. According to the figurative expression of Professor V.I. Podzolkov, the mechanism of obesity is based on the “three pines”. This is energy consumption, its expenditure, as well as the deposition of this difference in adipose tissue. What should be the treatment for obesity? Naturally, lifestyle changes come first: increasing physical activity and reducing caloric intake. This is followed by pharmacological therapy and only in last place is surgical weight correction. Current recommendations are:
- BMI 25-27 – only diet is used
- BMI 27-30 – diet, lifestyle changes
- BMI 30-35 – pharmacotherapy is added
- BMI over 35 – surgical correction is added
- The diet involves reducing caloric intake by 500-1000 kilocalories per day. Behavioral therapy also includes the work of psychologists. Of course, self-control on the part of patients is necessary. The patient must know why he is losing weight and be able to restructure his thinking. A difficult but necessary task. Pharmacological therapy has undergone advances in recent years. Hopes are pinned on rimonabant, a cannabinoid receptor blocker. However, the results of the 2006 trial were "moderately successful." This once again confirms the need for an integrated approach to the treatment of obesity. It is also important that short-term sharp weight loss does not produce significant positive results. Moderation and accuracy are required. The deadly quartet (obesity, dyslipemia, diabetes mellitus and hypertension) require treatment to influence each of the components. There is a clear connection between BMI and hypertension, including during drug treatment.
Hypertension is treated with a huge arsenal of drugs. However, today only 2 groups of antihypertensive drugs do not have undesirable effects: AT-1 receptor blockers and I-1 imidozoline receptor agonists. What is very important? These drugs promote weight loss, being metabolically neutral. When we talk about imidozoline receptors, we mean an effect on sympathetic activity. Moxonidine ( Physiotens ) reduces the level of circulating FFAs, improves the action of insulin, improves glucose utilization, and therefore reduces endothelial dysfunction. Thus, Physiotens breaks the pathogenetic mechanisms of development of the cardiovascular continuum. The drug also reduces microalbuminuria, a marker of the cardiac continuum. Physiotens reduces the formation of catecholamines and, importantly, acts on the renin-angiotensin system. The effect on hemodynamics is to reduce peripheral resistance. Physiotens . The drug is able to keep blood pressure at a stable level for years, which is also important. Comparison with other classes of drugs showed the same effectiveness as many well-known brands.
The results of the symposium allow us to draw a logical conclusion: Physiotens , as a drug recommended by the VNOK, makes it possible to treat arterial hypertension associated with excess body weight much more effectively than other groups of drugs. We can only hope that these recommendations will be put into practice in the near future.
Multicenter studies have shown that in terms of the effect on blood pressure, Physiotens is comparable to calcium blockers and ACE inhibitors, but has significantly better indicators of influence on various parts of the pathogenesis of MS. Another universal marker is microalbumin as an indicator of kidney damage and even the cardiovascular continuum. It turned out that Physiotens . has a positive effect on this marker. Thus, Physiotens . not only affects various parts of the pathogenesis of metabolic syndrome, but also reduces the risks of diseases associated with MS. At the end of the speech, Professor V.I. Podzolkov recalled the well-known truth: “Whoever has a smaller waist has a longer life,” so everything must be done to make the waist thinner and life longer.
Internet project "RMS-Expo" E-mail Web: Expo.rusmedserv.com
Physiotens: Russian analogues
Physiotens, in addition to providing first aid for hypertension, also has a positive effect on the heart muscle. With long-term use, blood flow in the capillaries is restored. The drug is produced in Germany; there are also analogues of this product in Russia.
Analogue of Physiotens
Analogues of Physiotensa made in Russia:
- Moxonidine - C3, Moxonidine-Akrikhin, Moxonidine-Canon
- Felotens, Moxonidine, Moxonidine-Avexima, Moxarel.
Physiotens: can it be taken with a high pulse?
The instructions indicate that Physiotens in large dosages can adversely affect the functioning of the heart. The patient exhibits drowsiness, bradycardia, dry mouth and a number of other unpleasant symptoms. So you can take it freely when your heart rate is high. This technique will reduce your heart rate per minute. The patient will receive sedation.
Pressure changes, what drug to use?
Interaction
Possible combined use with thiazide diuretics, ACE inhibitors and slow calcium channel blockers. There is a mutual enhancement of action when used together with these and other antihypertensive drugs.
There is no pharmacokinetic interaction with hydrochlorothiazide (combined use is possible), glibenclamide (glyburide), digoxin. Tricyclic antidepressants may reduce the effectiveness of centrally acting antihypertensive drugs (co-administration is not recommended). Moderately enhances reduced cognitive performance in patients taking lorazepam. Strengthens the sedative effect of benzodiazepines. There is no pharmacodynamic interaction when co-administered with moclobemide.
Physiotens: reviews from cardiologists
Elena Yakusheva:
The drug is ideal for patients with periodic hypertensive crises. If you use the pills correctly, there will be a productive result. Physiotraining reduces heart rate. For continuous use, it is better to use other dosage forms. Otherwise, you can get persistent bradycardia.
Maxim Leonidovich:
I believe that Physiotens is suitable for emergency cases, when there is a sharp increase in blood pressure, and for long-term use. Because of it, bradycardia may occur, but this is when the dosage of the drug does not correspond to the norm and it is used uncontrollably. The price of Physiotens is high, which is why many people buy analogues. Captopril is less effective in this matter.
Eduard Vadimovich:
Physiotens is a suitable drug for patients who suffer from diabetes. Due to long-term use, patients lose weight (slightly). Due to adverse reactions, panic attacks are possible. Anyone who has no experience taking the drug should know about this, and the attending physician should definitely tell him about it.
Pharmacodynamics
Selectively interacting with imidazoline I1 receptors located in the brain stem, it reduces sympathetic activity.
Moxonidine has a high affinity for imidazoline I1 receptors and only slightly binds to central alpha2 adrenergic receptors due to interaction with which dry mouth and sedation are explained.
Reduces tissue resistance to insulin.
Effect on hemodynamics: a decrease in systolic and diastolic blood pressure with single and long-term use of moxonidine is associated with a decrease in the pressor effect of the sympathetic system on peripheral vessels, a decrease in peripheral vascular resistance, while cardiac output and heart rate do not change significantly.
Physiotens: reviews of patients who took these tablets
Tatyana, 34 years old:
After the New Year, my mother’s blood pressure rose to 190/100. We tried giving the Capoten tablet under the tongue, but there was no result. They called an ambulance, but there were no cars, they promised to arrive in an hour. We didn’t want to waste time, so we went to the pharmacy, where the pharmacist advised us to take Physiotens. After taking these pills, my mother immediately felt better, within an hour the headaches went away and her blood pressure returned to normal. They called an ambulance but refused the call.
Nona, 46 years old:
I have been using the drug for almost two years as prescribed by my doctor. There is a whole treatment regimen prescribed there. According to the prescription, it must be consumed strictly in the morning, thanks to this my blood pressure is normal. I experienced no side effects. I am under the supervision of my doctor and have a cardiogram every three months. When taking such drugs for a long time, you should definitely monitor your heart rate, blood pressure and heart function.
Alexandra, 39 years old:
Towards the evening I had a headache, I took my blood pressure, the readings were 155/100 and my pulse was higher than normal. My mother advised me to take Physiotens, the smallest dosage. She had just these pills in her medicine cabinet. I drank it, after half an hour the headache stopped hurting, and my blood pressure returned to normal. But I felt some panic and dizziness. I was scared. After which I decided to try to sleep. In the morning I woke up, there were no more side effects, I felt completely healthy. I still advise you to pay attention to the instructions for the drug, it indicated side effects, and Physiotrenz is still better to use in patients with the second or third degree of hypertension, and not with pressure values like mine. Moreover, I experience such pressure extremely rarely. Consult your doctors before using such serious means to avoid harming yourself.
On our website you can also read articles on the topic of cardiovascular health:
- Magnesium B6 – instructions for use;
- Blood pressure norms for women and men after 50;
- What are the normal heart rates for people by age?
- Bisoprolol is a drug used for chronic heart pathologies;
- How to measure blood pressure correctly?
