Validol is often prescribed as a combination therapy for the treatment of angina. It can be purchased in pharmacies in free form in the form of tablets, capsules and drops.
Validol under pressure is used in combination with other drugs. It has a calming effect and promotes the dilation of blood vessels, which reduces their load, normalizes blood flow and thereby reduces pressure.
Despite its effectiveness, in case of a severe crisis you can only count on a calming effect, because the indirect effect of the drug will not be able to adequately reduce blood pressure to the desired values in a short time. People with hypotension are also advised to use the drug with caution.
Effect on pressure
Taking Validol in combination with other substances during a hypertensive crisis relieves pain and spasms. When a patient suffers from osteochondrosis, the drug reduces discomfort in the neck and sternum.
The drug is also indispensable for heart diseases, when the slightest stress or physical activity overwhelms the patient, increases the pulse rate, increases blood pressure and causes pain in the sternum.
One tablet can normalize the condition until the ambulance arrives.
A person's blood pressure can be either low with hypotension or high with hypertension.
With a sharp increase in pressure, Validol relieves spasms and dilates blood vessels, which, in combination with other medications, reduces pain and normalizes blood flow. As a result, the pressure drops, but in case of a severe attack, such treatment will not save the patient.
The drug is often used for atherosclerosis, as it eliminates the narrowing of blood vessels, which prevents blood from entering the brain. But this does not affect the reason itself in the form of strong pressure in the Validol stream.
What is the real purpose of validol?
Its range of applications is quite wide. Indications include the following conditions:
- Angina pectoris. In the case of this disease, validol is prescribed as one of the drugs in complex therapy.
- As a mild sedative, it is indicated for various neuroses: neurasthenia, hysteria, obsessive states, and also helps to recover from stress and depression. As a rule, it is prescribed in combination with other drugs.
Validol is available in tablet form
Despite the fact that validol is considered harmless, it still has a number of contraindications that you need to remember when you have the product in your home medicine cabinet. It should be taken with great caution or avoided in the following cases:
- for diabetes mellitus;
- with individual intolerance to menthol and valerian.
With prolonged and uncontrolled use, side effects may occur: lacrimation, nausea, dizziness.
Lowers or increases blood pressure
Blood pressure refers to a physical measurement that controls the force that the liquid component of blood presses against the walls of blood vessels from the inside.
When answering the question whether Validol lowers or increases blood pressure, it should be noted that it dilates blood vessels and, in complex therapy, slightly reduces blood pressure for a while and protects the vascular bed.
But this drug should not be used as the main treatment for hypertension, it can only be a last resort in emergency cases, after which you need to consult a doctor.
Moreover, the drug could not help in a severe crisis.
Low pressure application
In turn, those who suffer from hypotension may be interested in the question of whether validol increases or decreases blood pressure, and whether it can be taken by hypotensive patients as a sedative.
Doctors warn people suffering from low blood pressure that this drug may be dangerous for them. In this case, taking validol can lead to a drop in blood pressure, which may result in changes in the brain due to oxygen starvation. Therefore, hypotensive patients should consult a cardiologist for advice before taking validol. If your blood pressure is consistently low, it may be worth finding another drug with a similar effect.
Operating principle
The center contains menthol and isovaleric acid. The latter is obtained by artificial synthesis or from natural valerian root. It is this composition that helps achieve a sedative effect, normalizes blood circulation, relieving spasms and dilating blood vessels.
After taking the pill, the pain subsides, pulse and blood pressure return to normal values.
The principle of action of the drug is based on reflex reactions that occur when nerve endings are irritated.
When mucosal receptors are stimulated, the production of hormones responsible for controlling blood vessel permeability and pain is accelerated. There is a sudden release of large amounts of peptides, dynorphins, enkephalins and endorphins.
Histamines and kinins, which are active endogenous compounds, are also released. In addition, irritation of nerve fibers causes dilation of blood vessels.
Composition of validol
In order to understand how validol affects blood pressure, you need to get acquainted with its composition. Knowing how the drug works, namely whether it increases or decreases blood pressure, is important for all people whose blood pressure is not normal. Otherwise, you can simply harm your health.
The drug is available in tablets and drops. The components included in its composition do not cause harm to health. Among them:
- Valerian. It contains organic acids: formic, acetic, malic, stearic, palmitic. It is a sedative, helps get rid of insomnia, and has a positive effect on the functioning of the heart.
- Menthol. Present in validol in the form of a special solution in valerian ether. It has a sedative effect, relieves tension, anxiety, irritability, dilates coronary vessels, and acts as an antispasmodic.
Use of the drug for high blood pressure
Hypertension usually occurs as a result of vasoconstriction. Validol promotes the expansion of blood vessels, reducing pressure on them.
In addition to normalizing blood circulation, it eliminates nervousness if it is caused by stress, mental overload, which has a positive effect on both the pulse and general condition.
However, this drug is unlikely to be a panacea for hypertension, since its effect is indirect, short-term and in most cases only symptomatic.
The tablet or capsule should be placed under the tongue until completely dissolved. During the day you are allowed to take no more than 4 pieces. The effect is noticeable after 5-7 minutes.
If relief does not come even after 20 to 30 minutes, it is a sign that other medications should be preferred.
After taking the medicine, it is best to lie down. In some cases, you may be able to take another dose right away.
In liquid form, the drug is used for high blood pressure, applying 3 drops to a piece of sugar and holding in the mouth until dissolved. Do not take more than 20 drops per day. Sometimes it is recommended to increase the dose of the drug.
Validol
Validol
Registration number : LP-000612
Trade name : Validol
Group name : Levomenthol solution in menthyl isovalerate&
Dosage form: sublingual tablets.
Compound:
Active ingredient: levomenthol solution in menthyl isovalerate (validol) 0.06 g.
Excipients: sucrose (sugar) – 0.9216 g, calcium stearate monohydrate – 0.0098 g.
Description: flat-cylindrical tablets, beveled and scored, white with a yellowish tint with grayish inclusions, with a characteristic menthol odor
Pharmacotherapeutic group: coronary dilating agent of reflex action.
ATX code : [C01EX]
Pharmacological properties
Pharmachologic effect. It has a sedative effect and has a moderate reflex vasodilator effect due to irritation of sensitive nerve endings. Stimulates the production and release of enkephalins, endorphins and a number of other peptides, histamine, kinins (due to irritation of mucosal receptors), which are actively involved in the regulation of vascular permeability and the formation of pain. When administered sublingually, the therapeutic effect occurs on average within 5 minutes, with up to 70% of the drug released within 3 minutes.
Pharmacokinetics. When administered sublingually, levomenthol is absorbed from the oral mucosa, metabolized in the liver and excreted by the kidneys in the form of glucuronides.
Indications for use
Functional cardialgia, hysteria, neuroses, headache while taking nitra-
Tov, motion sickness syndrome (nausea, vomiting due to sea and air sickness).
Contraindications
Hypersensitivity, sucrase/isomaltase deficiency, fructose intolerance, glucose-galactose malabsorption (since the drug contains sucrose).
Carefully
With diabetes mellitus (the drug contains sugar).
Use during pregnancy and breastfeeding
Prescription of the drug during pregnancy and breastfeeding is possible if the expected benefit to the mother outweighs the potential risk to the fetus and child.
Directions for use and doses
Validol is prescribed to adults, 1 tablet under the tongue until it is completely absorbed. Take 1 tablet 2-3 times a day. The frequency and duration of administration is determined depending on the effectiveness of treatment. If the therapeutic effect is absent or insufficiently expressed, another therapy must be prescribed within the next 5-10 minutes after administration.
Side effect
Nausea, lacrimation, dizziness.
Overdose
Symptoms: headache, nausea, agitation, cardiac dysfunction, sharp decrease in blood pressure, depression of the central nervous system.
Treatment: discontinue the drug. Symptomatic therapy.
Interaction with other drugs
When used together with drugs that depress the central nervous system, it enhances the effect of the latter.
The simultaneous use of Validol with nitrates reduces the headache that occurs when using them.
special instructions
Should be prescribed with caution to patients with diabetes mellitus (for medicines containing sugar).
When taking Validol, you must be careful when driving vehicles and engaging in other potentially hazardous activities that require increased concentration and speed of psychomotor reactions.
Release form
Sublingual tablets 60 mg.
10 tablets in a blister pack made of polyvinyl chloride film and aluminum foil.
2 or 3 blister packs together with instructions for use are placed in a cardboard pack for consumer packaging.
It is allowed to place blister packs with an equal number of instructions for use in a cardboard box (multiple packaging).
Storage conditions:
In a dry place, protected from light, at a temperature not exceeding 25°C.
Best before date:
3 years. Do not use after the expiration date.
Units:
pack
Drug and heart disease
Validol is often used for pathologies of the “main engine”; it helps eliminate pain in the heart and head. In the absence of contraindications, it is suitable for long-term use.
Basically, blood pressure increases with bradycardia, angina or pre-infarction, and with these pathologies the drug can harm the patient.
This is due to the fact that only the symptoms are alleviated and the person receives relief, but the contraction of the heart itself persists and soon leads to a heart attack or necrosis of cardiac tissue.
In this case, it is quite difficult for a doctor to make a diagnosis, since the picture of the pathology is blurred.
Mechanism of action and composition of the drug
Validol refers to drugs that have a stimulating effect on peripheral nerve receptors located in the mucous membranes. In addition to the main component of the medicine, there are auxiliary ingredients.
| Substance | Group | Mechanism of action | Effect |
| A solution of menthol in isovaleric acid menthyl ester | Drugs with reflex action | Irritation of peripheral nerve endings (cold receptors) leads to the release of opioid proteins (endorphins, enkephalins, dynorphins), which reduce pain and affect vascular permeability. The cutaneous-visceral reflex is triggered: local vasoconstriction correlates with an improvement in the trophism of the internal organs (corresponding to the innervation of the segment). | Local: irritant, anti-inflammatory. Remote (reflex): expansion of coronary vessels (antianginal), toning of vein walls, analgesic effect, mild hypnotic effect (due to depression of the central nervous system) |
| Calcium stearate | Basic tools | Stabilizer of a mixture of different components, ensures the plasticity and integrity of the final substance | |
| Sugar | Sweeteners | Improves organoleptic (taste) qualities | |
The composition of Validol is based on menthol. The most significant effect is the ability, when irritating receptors in the oral mucosa, to trigger a reflex arc, which leads to dilation of the coronary vessels.
According to the instructions, this pharmacological agent is available without a prescription.
When is it appointed?
Due to its sedative and hypotensive properties, the drug has a wide range of indications. It is prescribed for:
- Mental overload, stress, neuroses.
- Hysteria.
- Pain in the area of the heart, sternum. But only in case of pain, pressing discomfort, it is better to exclude Nitroglycerin.
- Hypertension.
- Seasickness.
- Cardiopalmus.
- Convulsions are provoked by cervical and thoracic osteochondrosis.
It does not accumulate in the body and has virtually no side effects.
Indications for use
Validol is prescribed if the following indications exist:
functional cardialgia (in the absence of a morphological substrate for damage to the heart muscle and pronounced myocardial hypertrophy);- angina pectoris of an angioedema nature (accompanied by increased heartbeat);
- mild forms of coronary heart disease (as one of the components of complex therapy);
- neuroses (accompanied by tachycardia due to stress);
- attacks of hysteria (as a sedative and to reduce heart rate - HR);
- exposure to attacks of “sea” and “air” sickness (in the case when it has a neuropsychological origin);
- headache (caused by taking nitrates, such as nitroglycerin).
Even if a person finds indications for the use of Validol, this is not a sufficient reason to take the medication. Specialist consultation is required.
A contraindication for the use of Validol is the lack of individual compatibility and intolerance to any of its components.
Side effects and symptoms of overdose
With long-term use, the following side effects may occur:
feelings of nausea;- tearfulness;
- feelings of loss of orientation in space and dizziness;
- low blood pressure (hypotension is transient);
- drowsiness;
- increased flatulence (discharge of intestinal gases);
- allergic reactions (Quincke's edema, rash on the skin and mucous membranes, itching).
After stopping taking Validol, the symptoms quickly disappear on their own.
Symptoms of exceeding the dose of this medication are a clear manifestation of side effects in combination with nervous excitement, cardiac dysfunction, a drop in blood pressure and depression of the functions of the central nervous system.
In case of overdose and symptoms of poisoning occur, it is necessary to immediately discontinue the drug, organize gastric lavage and administer desensitizing agents.
