In many people's medicine cabinets you can find Validol. This cheap but effective drug has a quick effect, helps relieve nervous tension, rapid heartbeat, and normalize blood pressure. Indications for the use of Validol are quite wide; it is used as a vasodilator, sedative, and analgesic. A wide spectrum of action and rapid onset of therapeutic effect make Validol in demand and popular for many years.
Compound
According to Wikipedia, the INN (international nonproprietary name) of Validol is levomenthol solution in menthylisovalerate , chemical formula is C15H28O2.
Composition of Validol tablets: 60 mg of levomenthol solution in menthylisovalerate - the active ingredient. Additional components: calcium stearate, sucrose.
Composition of Validol in capsules: 50 mg or 100 mg of levomenthol solution in menthylisovalerate - the active ingredient. Additional ingredients: pharmaceutical gelatin, methyl parahydroxybenzoate, glycerol , propyl parahydroxybenzoate, purified water.
Pharmacodynamics and pharmacokinetics
Validol is a complex substance obtained during the process of dissolving menthol (levomenthol) in menthylisovalerate (menthyl ester of isovaleric acid). In the case of sublingual use of validol , for which tablets or capsules of the drug should be placed under the tongue, its pharmacological effect is manifested due to the influence of its two active ingredients - menthol and menthylisovalerate .
The action of menthol in the oral cavity is aimed at irritating the nerve endings located on the mucous membrane. It has been proven that such irritation leads to a reflex dilation of blood vessels (including coronary vessels).
The effect of menthylisovalerate is manifested due to its ability to stimulate in the central nervous system the production and further release of peptides ( dynorphin , endorphin , kinin , enkephalin ) and the mediator histamine , which are regulators of pain and vascular permeability . In this case, the combined effect of these substances acts as an analgesic and sedative compound.
As a result of the general effect of the active ingredients of validol, the observed pain sensations , peripheral blood circulation , and a calming (sedative) effect is manifested, from which validol helps with various painful conditions associated with the cardiovascular system.
Absorption of the active ingredients of the drug in the oral cavity occurs very quickly and within a few minutes their maximum concentrations circulate in the systemic bloodstream. The effect of validol , in the case of its sublingual use, is felt within 3-5 minutes.
Partial transformation of validol occurs in the liver with the formation of products ( glucuronides ) excreted in bile and urine, as well as in the air exhaled by a person.
conclusions
Validol is a menthol-based drug that has been prescribed by therapists and cardiologists for decades. Modern experts question its effectiveness, comparing it with placebo.
Validol does not have a pronounced effect, and as a preventive measure for increasing the area of necrosis during myocardial infarction, it will be ineffective. However, in case of minor functional disorders of the heart caused by overstrain of the nervous system, this drug has the necessary sedative and vasodilating effect in sufficient quantities.
Analogues of Validol: Corvalment, Lily of the valley-valerian drops.
Indications for use of Validol
Indications for use of Validol are:
- states of hysteria ;
- functional cardialgia ;
- various neuroses ;
- sensations of headaches ,
- arising during nitrate ;
- motion sickness syndrome (including symptoms of nausea / vomiting due to air and/or seasickness ).
Using pills during pregnancy
Is it possible or not to take Validol while bearing a child, because during this period the use of medications is prohibited? Doctors allow the use of tablets, provided that the woman does not have hypersensitivity to the active components. Validol will help alleviate the well-being associated with increased nervousness and anxiety, improve sleep and slightly lower blood pressure, because many women experience an increase in blood pressure during pregnancy.
However, before using the tablets, consultation with your doctor is required, despite the availability and harmlessness of the drug. Another advantage for pregnant women is the ability to eliminate the urge to nausea and vomiting, which many suffer during early toxicosis (in the first trimester). Validol is effectively used to relieve motion sickness, so it will remove the discomfort caused by toxicosis.
Contraindications
Before taking Validol tablets or capsules, you must familiarize yourself with the contraindications to their use, which include personal hypersensitivity to the ingredients of the dosage form of the drug and the pathology of sugar intolerance (if they are present in the dosage form).
sucrose as an additional component , which is why Validol tablets should be taken with caution by people suffering from diabetes .
Description
The tablets are white or with a yellowish tint. Sometimes they are produced with grayish inclusions. The shape is flat-cylindrical, the medicine has a noticeable menthol smell.
Capsules with a gel-like shell, soft to the touch. Inside there is a clear oily liquid with a menthol smell.
The solution is produced in ampoules of 5 ml, has a thick oily consistency, and a strong menthol odor.
Important! Some believe that Validol contains peppermint and valerian. This is wrong. Some manufacturers do indeed include impurities in the drug, but there are very few of them.
Side effects
allergic manifestations may occur , including itching / rash on the skin, Quincke's edema and urticaria .
The use of validol in large dosages and over a long period of time can lead to lacrimation , dizziness and nausea . These manifestations usually disappear when dosages are reduced or therapy is temporarily discontinued.
Instructions for use of Validol
Before starting therapy with Validol, it is advised to establish the body’s personal sensitivity to its ingredients and, depending on their tolerance, determine how many tablets or capsules can be taken in 24 hours and whether taking large dosages is harmful in this particular case.
Capsules and tablets Validol, instructions for use
Instructions for use of Validol in capsules and tablets recommend their sublingual (under the tongue) use. Any form of the drug should be placed in the oral cavity under the tongue and kept there until it is completely absorbed. A single dose is considered to be one tablet (60 mg) or one capsule (50 mg or 100 mg). The average number of daily doses is 2-4 times, the maximum allowable dosage in 24 hours is 600 mg (10 tablets; 12 capsules of 50 mg or 6 capsules of 100 mg). It is better to limit the duration of alternating courses of therapy to 7 days. If the drug has zero or insufficient effectiveness 5-10 minutes after its complete absorption, the possibility of using other drugs should be considered.
Instructions for using Validol with glucose are identical to the above description.
Drug substitutes
The Radar Directory includes the following Validol Analogs:
- Cormenthol - has a similar effect, is available in the form of capsules, which are intended for use under the tongue. Indications for use: neuroses, high blood pressure, hysteria, antiemetic for sea and air sickness;
- Corvalol is a combined antispasmodic, sedative medicine used for various cardiovascular pathologies. The drug is available in capsules and drop form. Contains alpha-bromoisovaleric acid ethyl ester, sodium phenobarbital, peppermint oil and other components;
- Riboxin is a drug with a metabolic effect, one of the precursors of ATP. Riboxin is prescribed for diseases of the heart and blood vessels, for the treatment of coronary artery disease, myocarditis, heart defects and other conditions. The product is produced in the form of tablets, capsules, solution for injection;
- Corvalment – has the international name Corvalmentum. The therapeutic effect of this drug is due to the menthol included in its composition. The drug is used for the symptomatic treatment of angina pectoris, neuroses, hysteria and other conditions. Corvalment has a sedative, vasodilator, and mild hypnotic effect.
Only a few analogues of Validol are described above. The list of drugs that have a similar effect is very extensive. To prescribe one or another remedy, you should consult a doctor.
Overdose
Taking large doses of the drug leads to Validol lowering blood pressure or increasing the risk of side effects and their severity.
Overdose, that is, the use of an excessive number of tablets or capsules at a time, enhances both the positive and negative effects of the drug and can lead to a sharp decrease cardiac function , , the formation of severe headaches and severe nausea leading to vomiting , overexcitation and even depression functionality of the central nervous system.
In this case, depending on the observed manifestations and their intensity, symptomatic treatment .
special instructions
Shelf life – 24-36 months (depending on the manufacturer). It should be stored in a dark place at a temperature of 9-16 degrees.
It is not recommended to take the drug in parallel with alcoholic beverages, since alcohol can have a suppressive effect on the central nervous system, which can lead to more severe adverse reactions.
If you use Validol together with psychotropic drugs, the effectiveness of the latter will increase.
After taking it, you should stop driving for a while.
Interaction
Parallel use with opioid analgesics , psychotropic drugs , ethanol-containing drugs and anesthesia drugs increases their effects.
Combined use with nitrates reduces the feeling of headache that occurs during their use.
Combined use with antihypertensive drugs may potentiate their effectiveness.
Features of use for concomitant pathologies
for headaches caused by the use of nitrates (they provoke dilation of intracranial vessels and, accordingly, a local increase in pressure), Validol successfully helps;- this drug enhances the sedative effect of psychotropic drugs (there is a danger of developing apatho-abulic disorders), opiates (a possible fatal complication is depression of the respiratory center until breathing stops completely), anesthesia (there is a risk of transition to a coma);
- in the presence of a hangover, taking Validol will significantly aggravate the existing symptoms;
- Validol has the ability to lower blood pressure (due to its calming and vasodilating effects), but it should not be used to prevent hypertensive crises;
- if the patient receives drug therapy for hypertension, it is necessary to take into account the ability of Validol to potentiate the effect of antihypertensive drugs (there is a danger of iatrogenic hypotension - a provoked decrease in pressure);
- during pregnancy, the drug can be used after consultation with a doctor in the case when the expected positive effect exceeds the possible negative effect of the drug on the fetus;
- During lactation, Validol can be used, but with caution, since active release of this medication into milk is not observed during feeding, but extensive clinical studies have not been conducted;
- Alcohol and Valocordin are not compatible.
Alcohol initially has a dilating effect on the blood vessels, but eventually they spasm. Such a sharp change in the tone of the walls of arterioles and venules can provoke an attack of arrhythmia. During heavy drinking, frequent changes in the volume of the bloodstream can lead to serious consequences (stroke, asystole - lack of pulse).
Analogs
Level 4 ATC code matches:
Eltacin
Tonginal
Tricardin
Instenon
Pumpan
Barboval
Corvalment
If for some reason the use of Validol is impossible, doctors can recommend the following analogues:
- Advocard;
- Gulidol;
- Cardiolin;
- Dystonin;
- Cardiofit;
- Cormenthol;
- Kratal;
- Pumpan;
- Barboval;
- Tonginal;
- Instenon;
- Rhythmocore;
- Tricardin , etc.
Validol during pregnancy and lactation
The question of whether pregnant or breastfeeding women can take sedatives should be considered on a case-by-case basis, with the understanding that even when a single dose of a minimal dose of a sedative is completely normal, continued use may cause harm to the fetus, mother or breastfeeding child. to kid. In this regard, deciding whether Validol can be taken during pregnancy and breastfeeding should be left to the consideration of the attending physician.
Comparison with other drugs
Patients are often interested in which is better – Validol or Corvalol. Some people are interested in the question, which product should be preferred, Nitroglycerin or Validol? Doctors unanimously say that choosing medications on your own is not recommended. Each product has a specific effect and must be used strictly as prescribed by a specialist. Each of these drugs has a similar effect. This is what gives rise to so many questions. Be that as it may, it is impossible to accurately answer which of the remedies is better. The doctor selects the drug individually for the patient, based on his condition and diagnosis.
Reviews about Validol
The vast majority of people leave purely positive reviews about Validol, especially when this drug is used occasionally to relieve various anxiety , stress or other similar conditions. Also, this medicine copes well with headaches nitrate therapy , and is a weak hypnotic and hypotonic .
Validol price, where to buy
The price of Validol, depending on the manufacturer and the number of tablets or capsules in secondary packaging, varies slightly, but still remains affordable for any consumer, since you can buy 10 tablets or capsules of the drug for 30-40 rubles.
- Online pharmacies in RussiaRussia
- Online pharmacies in UkraineUkraine
- Online pharmacies in KazakhstanKazakhstan
ZdravCity
- Validol capsules 50 mg 40 pcs Lumi LLC
42 rub. order - Validol sublingual tablets 60 mg 10 pcs Usolye-Sibirsky Chemical Pharmaceutical Plant OJSC
38 rub. order
- Validol caps. roach 100 mg 20 pcs JSC Marbiopharm
50 rub. order
- Validol tablets 60mg 16pcs AO Update PFK
87 RUR order
- Validol sublingual tablets 60mg 10pcs JSC Tatkhimfarmpreparaty
36 RUR order
Pharmacy Dialogue
- Validol (caps. 0.05g 20 pcs. pack. cell. contact. (2), packs of cards) Lumi LLC
36 RUR order
- Validol Avexima (tab. 60 mg No. 20) Irbitsky HFZ
52 RUR order
- Validol (tab. 60 mg No. 10) TCPP
36 RUR order
- Validol (caps. 100 mg No. 20) Marbiopharm OJSC
47 RUR order
- Validol (tablet. 60 mg No. 10) Usolye-Sibirsky CFC
45 rub. order
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Pharmacy24
- Validol 0.06 g N10 tablets PAT "Lubnipharm", Ukraine
3 UAH. order - Validol Darnitsa No. 10 tablets PrAT” Pharmaceutical company “Darnitsa”, Ukraine
4 UAH order
- Validol 0.06 g No. 10 tablets PAT "Farmak", Ukraine
4 UAH order
- Validol Darnitsa No. 6 tablets PrAT” Pharmaceutical company “Darnitsa”, Ukraine
3 UAH order
PaniPharmacy
- Validol tablets Validol tablets. 0.06g No. 10 Ukraine, Darnitsa ChAO
5 UAH order
- Validol tablets 0.06g No. 10 Ukraine, Farmak
4 UAH order
- Validol tablets Validol tablets. 6mg No. 10 Ukraine, Lubnyfarm PJSC
4 UAH order
- Validol tablets Validol tablets. 0.06g No. 6 Ukraine, Darnitsa ChAO
3 UAH order
- Validol tablets Validol tablets. 0.06g No. 6 Ukraine, Lubnyfarm PJSC
2 UAH order
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