Selank 0.15%
"Selank" - an innovative drug for regulating brain functions
“Selank” is a medicine developed in the mid-2000s by scientists from the Institute of Molecular Genetics of the Russian Academy of Sciences and the V.V. Research Institute of Pharmacology. Zakusova.
"Selank" - effective help with stress and mental stress
Initially, “Selank” was created as a drug for nerves and stress to support the emotional sphere and brain activity of people whose lives pass in a busy working rhythm. The product is based on a peptide obtained by synthesizing tuftsin. The ability of tuftsin to relieve states of fear and anxiety, as well as to support improved mental activity, was used by scientists who synthesized “Selank”.
"Selank" - a sedative for depression
Modern life is replete with reasons that force most people to live in a state of constant stress. Moral depression can result in long-term, intractable depression.
"Selank" acts as an effective remedy for depression , a cure for insomnia and low tone, normalizing extreme emotional states.
“Selank”, as a result of research and clinical use, has shown its effectiveness as a cure for fear, anxiety and restlessness . The drug helps to cope with neurasthenic symptoms of anxiety and fear, the regular presence of which further provokes depression, insomnia, headaches, fatigue, and mood swings. The effectiveness of its impact on the psycho-emotional sphere of a person allows it to be used in psychiatry and neurology and as a cure for depression .
"Selank" - indications for use
People susceptible to psycho-emotional lability are unable to get rid of overstrain even after a long rest. Both people with mental work (students, students, scientists, managers, office workers) and those actively engaged in physical work - athletes, military personnel - are subject to heavy loads. Also, everyday everyday stresses have a huge impact on a person’s condition: conflicts at work and in the family, financial difficulties, problems with loved ones, and so on.
Main indications for use of the drug "Selank"
- states of anxiety and restlessness;
- panic attacks;
- neurasthenic and asthenic syndrome;
- decreased will;
- indecision and uncertainty in communication;
- difficulty making decisions;
- adjustment disorders;
- treatment and prevention of post-stress disorders.
Advantages of Selank
Selank is one of the few medications for depression and stress that can be bought without a prescription. Most drugs with a similar mechanism of action are available in tablet form, but tablets are for nerves and stress . can be replaced by a more effective method of drug delivery - Selank nasal drops.
“Selank” does not cause addiction, drowsiness, or allergic reactions. The drug is combined with other drugs, can be used when driving cars and machinery, and is also compatible with alcohol, which expands the possibilities of its use as a medicine for anxiety and stress . Selank drops, instead of tablets or injections, are convenient, easy to use and 92.8% bioavailable. The effect of the drug begins a few minutes after administration and lasts for 24 hours.
FeminaTabs lozenges 30 pcs
Active substance:
Vitamin E (DL-alpha-tocopheryl acetate); trans-resveratrol (obtained from the roots of Japanese rhineutria (Polygonumcuspidatum Siebold&Zucc.); L-arginine; cholecalciferol (medium chain triglycerides, vitamin D3, alpha-tocopherol). Content of active substances in 1 tablet: Resveratrol - 10 mg; Vitamin D - 10 mcg; Vitamin E - 12 mgTE
Excipients:
Cellulose, polyvinylpolypyrrolidone, isomalt, carboxymethylcellulose sodium salt three-dimensional, silicon dioxide, mono- and diglycerides of fatty acids, fatty acids, magnesium salt of fatty acid, medium chain triglycerides, polyoxyethylene sorbitan monooleate, esters of fatty acids and ascorbic acid, pectins, natural lemon flavoring , sucralose.
Description:
Feminatabs® is a dietary supplement specially developed for women and is an additional source of resveratrol, vitamins D and E. Thanks to the special SUBLINGUAL NANOTABLET TECHNOLOGY© tablets, when administered sublingually (under the tongue), quickly dissolve and are absorbed in the oral cavity. This method of application avoids partial destruction of the product due to the effect of first passage through the liver and, thus, ensures high bioavailability of the active ingredients and the speed of achieving the effect*.
Component properties:
Resveratrol: Resveratrol is a naturally occurring phytoestrogen with estrogen-like and antioxidant effects that contribute to its multidirectional anti-aging effects*; Resveratrol is a powerful antioxidant that helps protect the body from the effects of free radicals and lipid peroxidation. Helps preserve collagen, elastin and hyaluronic acid in tissues, thereby preventing age-related changes in the skin, moisturizing and maintaining its elasticity and firmness*; In menopausal women, it helps reduce symptoms of estrogen deficiency, including hot flashes and night sweats*. Trans-resveratrol has a beneficial effect on vascular blood flow, including in the vessels of the brain, allowing the preservation of cognitive functions*.
Vitamin E: Vitamin E is a natural antioxidant and when used together with resveratrol enhances its antioxidant effect. The use of vitamin E helps improve the condition of skin, nails and hair*.
Vitamin D: Vitamin D3 is essential for maintaining skeletal health and preventing osteoporosis, as well as maintaining muscle strength, overall tone and immunity. With hormonal disorders, especially with estrogen deficiency during menopause, women have an increased need for vitamin D3*.
Feminatabs® is: • new** generation phytoestrogens from Abbott*; • non-hormonal support for women's health*; • a new combination of resveratrol with vitamins D and E aimed at combating age-related changes*.
**The term “new generation” refers to the sublingual form of delivery of trans-resveratrol, one of the components of the product; *Sources: - E.A. Vinokurova et al. New possibilities for personalized menopausal herbal medicine with resveratrol // Doctor.RU, Gynecology, Vol. 20, No. 6 (2021); — Uspenskaya Yu.B. Clinical effects of resveratrol (literature review) // Gynecology. 2014. No. 5; — Davinelli S et al Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: A randomized, placebo-controlled study. Maturitas. 2021 Feb;96:77-83; — SIOP dated 04/21/2021 based on the SGR dated 03/22/2021; — Li YR, Li S, Lin CC. Effect of resveratrol and pterostilbene on aging and longevity. Biofactors. 2018 Jan;44(1):69-82. doi: 10.1002/biof.1400. Epub 2021 Dec 6. PMID: 29210129; — Uberti F, Morsanuto V, Aprile S, et al. Biological effects of combined resveratrol and vitamin D3 on ovarian tissue. J Ovar Res. 2017;10:61; — Aungst, L., & Rainer, S. (2014). Importance of Vitamin D to Postmenopausal Women's Health. The Journal for Nurse Practitioners, 10(9), 653–659; — Ziaei, S., Kazemnejad, A., & Zareai, M. (2007). The Effect of Vitamin E on Hot Flashes in Menopausal Women. Gynecologic and Obstetric Investigation, 64(4), 204–207; — Milia, R. (2015). Improvement of climacteric symptoms with a novel sublingual product containing transresveratrol. Progress in Nutrition. 17. 68-72; — Angelika Dampf Stone et al Resveratrol potentiates vitamin D and nuclear receptor signaling 2015 Jun;116(6):1130-43. doi: 10.1002/jcb.25070; — Amri A, Chaumeil JC, Sfar S, Charrueau C. Administration of resveratrol: what formulation solutions to bioavailability limitations? J Control Release 2012 Mar 10; 158(2): 182-93; — Fratter, A., & Semenzato, A. (2011). New association of surfactants for the production of food and cosmetic nanoemulsions: preliminary development and characterization. International Journal of Cosmetic Science, 33(5), 443–449; — Blanchard OL, Friesenhahn G, Javors MA, Smoliga JM (2014) Development of a Lozenge for Oral Transmucosal Delivery of Trans-Resveratrol in Humans: Proof of Concept. PLoS ONE 9(2): e90131. doi:10.1371/journal.pone.0090131; — Patent for Sublingual Nanotablet Technology® No. ITA 102016000022050, https://labomar.com/en/research-development/technology-patents/delivery-patents/; — Nutritionology and clinical dietetics. National Leadership, ed. V.A. Tutelyan, D.B. Nikityuka M.. GEOTAR-Media, 2020, pp. 105-107; — Chen ML, Li J, Xiao WR et al. Protective effect of resveratrol against oxidative damage of UVA irradiated HaCaT cells. Jhong Nan Da Xue Xue Bao Yi Ban 2006; 31: 635–9; — Lee TH, Seo JO, Baek SH, Kim SY. Inhibi ory effects of resveratrol on melanin synthesis in ultraviolet B-induced pigmentation in Guinea pig skin. Biomol Ther (Seoul) 2014; 22 (1): 35–40.
Release form:
30 tablets weighing 170 mg
General information
Trade name Galavit®
Registration number LSR-008746/09
INN or group name Aminodihydrophthalazindione sodium
Chemical name 5-amino-1,2,3,4-tetrahydrophthalazine-1,4-dione sodium salt
Dosage form Sublingual tablets
Release form
Sublingual tablets, 25 mg. 10 or 20 sublingual tablets in blister packs made of polyvinyl chloride film and aluminum foil. 1, 2, 3 or 4 contour packages along with instructions for use in a cardboard box. 10, 20, 30, 40 or 50 contour packs with an equal number of instructions for use in a group pack
Compound
Active ingredient - sodium aminodihydrophthalazindione (Galavit®) 0.025 g, excipients - sorbitol 0.315 g, starch 0.14 g, lactose 0.1 g, calcium stearate 0.005 g, talc 0.015 g and racementol (menthol) 0.0001 g. Description The tablets are white with a yellowish tint, biconvex, without a score, with a menthol odor.
Pharmacotherapeutic group
Immunomodulatory and anti-inflammatory agent.
ATX code L03
Pharmacological properties
Pharmacodynamics
The mechanism of action of the drug is associated with its ability to regulate the functional and metabolic activity of innate and adaptive immune cells (monocytes, macrophages, neutrophils, natural killer cells, etc.). Galavit normalizes the phagocytic activity of monocytes/macrophages, the bactericidal activity of neutrophils and the cytotoxic activity of NK cells. At the same time, by restoring the reduced activity of innate and adaptive immune cells, the drug increases the body’s resistance to infectious diseases of bacterial, viral and fungal etiology, promotes faster elimination of the pathogen from the body, and reduces the frequency, severity and duration of infections.
In addition, Galavit normalizes antibody formation, increases the functional activity (affinity) of antibodies, and indirectly regulates the production of endogenous interferons (IFN-α, IFN-γ) by producer cells. In inflammatory diseases, the drug reversibly inhibits for 6-8 hours the excessive synthesis of tumor necrosis factor-α, interleukin-1, interleukin-6 and other pro-inflammatory cytokines by hyperactivated macrophages, the level of which determines the degree of inflammatory reactions, their cyclicity, as well as the severity of intoxication of the body.
Galavit reduces the production of reactive oxygen species by hyperactivated macrophages, thereby reducing the level of oxidative stress and protecting tissues and organs from the destructive effects of radicals. Normalization of excessively increased functional activity of phagocytic cells leads to the restoration of their antigen-presenting and regulatory functions, and a decrease in the level of autoaggression. The drug is well tolerated and has no allergenic, mutagenic, embryotoxic, teratogenic or carcinogenic effects. Pharmacokinetics Excreted from the body mainly through the kidneys. When administered sublingually, the half-life is 30 minutes. The main pharmacological effects are observed within 72 hours.
Russia, 123290, Moscow, dead end Magistralny 1st, 5A, room. 91 Tel/fax 8-800-707-71-81 E-mail: [email protected] ; https://www.galavit.ru Address of production site 308013, Belgorod, st. Rabochaya, 14 Send claims to the address 123290, Moscow, dead end Magistralny 1st, 5A, room. 91. Tel. 8-800-707-71-81
Indications for use
In adults and adolescents over 12 years of age (including those with secondary immune deficiency) as an immunomodulatory and anti-inflammatory agent in complex therapy:
- acute respiratory infections, diseases of the respiratory tract and ENT organs (including often recurrent ones) of bacterial and viral etiology (ARVI, influenza, bronchitis, pneumonia, tonsillitis, otitis, adenoiditis) and their prevention;
- inflammatory diseases of the mucous membrane of the mouth and throat, periodontal diseases;
- chronic recurrent diseases caused by the herpes virus;
- decreased physical performance (including among athletes)
Directions for use and doses
Sublingually, 1 tablet up to 4 times a day or 2 tablets up to 2 times a day.
- For acute respiratory infections, flu, bronchitis, pneumonia, tonsillitis, otitis, adenoiditis for treatment: 1 tablet 4 times a day. Course 5 days.
- In case of chronic and frequent relapsing course, continue 1 tablet 4 times a day every other day for a course of up to 15 days.
- For prevention: 1 tablet 2 times a day. Course 5-10 days.
- For inflammatory diseases of the mucous membrane of the mouth and throat, periodontal diseases: 1 tablet 4 times a day for 5 days. Then 1 tablet 4 times a day after 3 days for a course of up to 3 weeks.
- For chronic recurrent diseases caused by the herpes virus: 1 tablet 4 times a day for 10 days. Then 1 tablet 4 times a day every other day for 10 days.
- To increase physical performance: 1 tablet 4 times every other day for 10 days, then 1 tablet 4 times a day after 3 days for a course of up to 3 weeks.
Treatment with Galavit can be started at any stage of the disease. Use the drug according to the indications, the method of administration and in the doses indicated in the instructions. If after these courses of treatment there is no improvement, or the symptoms worsen, or new symptoms appear, you should consult your doctor.
Precautionary measures
Contraindications
Individual intolerance, intolerance to galactose, fructose, lactase deficiency or glucose-galactose malabsorption, pregnancy and breastfeeding, children under 12 years of age.
Use during pregnancy and breastfeeding
The drug is contraindicated for pregnant women and women during breastfeeding.
Side effects
In rare cases, allergic reactions are possible. If you experience the side effects listed in the instructions or they get worse, or you notice any other side effects not listed in the instructions, tell your doctor.
Overdose
No cases of overdose have been reported.
Interaction with other drugs
With simultaneous use, it is possible to reduce the course doses of antibiotics. Galavit allows you to increase the effectiveness of antibiotic therapy and reduce its damage
The drug contains sorbitol; patients with rare hereditary pathologies associated with fructose and sorbitol intolerance should not take the drug.
Impact on the ability to drive vehicles and machinery
The drug does not affect the ability to drive vehicles or operate machinery.
Shelf life, storage conditions
Storage conditions: Store at a temperature not exceeding 25 ° C, in a place protected from light. Keep out of the reach of children.
Shelf life: 3 years. Do not use after the expiration date indicated on the carton.
Conditions for dispensing from pharmacies Dispensed without a prescription.
