Pharmacology
Panangin is an important source of microelements. The medication helps maintain electrolyte balance. Involved in the metabolic process, has an antiarrhythmic effect.
Potassium is responsible for the normal functioning of the heart, conducting nerve impulses along the fibers. With a lack of this substance, there is excitability of nerves and tissues. With a small amount of potassium, the coronary arteries dilate, and with a large dosage, a narrowing of the lumen is observed.
Magnesium is necessary for processes associated with the intake and expenditure of energy. The trace element is present in the pentose phosphate structure of DNA and is involved in the process of cell division and growth, and RNA synthesis. Magnesium is a natural blocker of slow calcium channels and prevents the release of free fatty acids.
The medicine is well absorbed. Exits through the kidneys.
Note!
Description of the drug Panangin forte table. p/o 280 mg/316 mg No. 60 on this page is a simplified author’s version of the apteka911 website, created on the basis of the instructions for use.
Before purchasing or using the drug, you should consult your doctor and read the manufacturer's original instructions (attached to each package of the drug). Information about the drug is provided for informational purposes only and should not be used as a guide to self-medication. Only a doctor can decide to prescribe the drug, as well as determine the dose and methods of its use.
How to use
Pills
The medicine in tablet form is intended for oral administration. You can take 2 tablets three times a day. For maintenance purposes, you can take 1 tablet three times a day. The treatment course is 20-25 days.
In special cases, an additional therapeutic course may be required.
Intravenous administration
Panangin in the form of a solution should be administered intravenously slowly, drip-wise. The rate of administration of the drug should not be more than 25 drops per minute. This procedure can be carried out no more than 2 times a day. No more than 300 ml can be administered at a time. The dosage of the medicine for pregnant women does not require adjustment and is carried out according to the standard scheme.
For prevention purposes
Patients are often interested in questions regarding the benefits and harms of a drug. It is worth understanding that Panangin can cause many negative reactions, so you should not use it for preventive purposes. This is explained by the fact that taking medications will cause the body to become accustomed to a certain content of microelements or may lead to an excess of these microelements in the human body, which will entail many negative consequences.
Compound
1 film-coated tablet contains:
280 mg magnesium aspartate (as 350 mg magnesium aspartate tetrahydrate);
316 mg potassium aspartate (as 332.6 mg potassium aspartate hemihydrate);
excipients: silicon dioxide colloidal povidone K-30; potato starch; magnesium stearate talc corn starch;
film shell: macrogol 6000; titanium dioxide (E 171) main copolymer of butylated methacrylate (eudragit E); talc.
Adverse reactions
The drug may cause the following side effects:
- the appearance of ulcers in the stomach;
- diarrhea;
- pain in the epigastric region;
- hemorrhage from the stomach, intestines;
- nausea, vomiting;
- feeling of dryness in the mouth;
- skin irritations;
- dizziness;
- excessive sweating.
With rapid intravenous infusion, an excessive increase in the amount of trace elements in the blood occurs.
Who is Panagin recommended for?
Panangin. Pills
Panangin is recommended for medicinal purposes:
- For cardiac arrhythmia (irregular heart rhythm) caused by electrolyte disturbances, mainly due to potassium deficiency in the blood
- For heart rhythm disturbances caused by intoxication with digitalis products
- For atrial rhythm disturbances
- For ventricular rhythm disturbances
- For coronary insufficiency
- For arterial hypertension
For disorders of myocardial metabolism, the cause of which is impaired blood circulation through the blood vessels of the myocardium and a decrease in the concentration of potassium in the blood as a result of taking diuretics. Panangin is recommended for all healthy people over the age of 45 for the purpose of nutrition and strengthening the heart and preventing cardiovascular pathologies.
Overdose
It is not recommended to exceed the prescribed dose. An overdose of the drug is possible, manifested by the following symptoms:
- excessive levels of potassium and magnesium ions in the blood;
- muscle hypotonicity;
- problems with the functioning of the heart, even to the point of cardiac arrest;
- arrhythmia;
- changes on the electrodiogram.
If such signs appear, you should immediately inject a solution of dextrose and sodium chloride intravenously. Depending on the patient's condition, peritoneal dialysis may be required.
Features of application
Pregnant
Use during pregnancy or breastfeeding.
There is still no evidence of any harmful effects when using the drug Panangin Forte in this category of patients.
Children
The safety and effectiveness of using Panangin Forte, film-coated tablets, in children and adolescents have not been established.
The use of the drug in this group of patients is not recommended.
Drivers
Panangin Forte does not affect the ability to drive vehicles and other machinery.
Combination with other medications
The drug may enhance the negative effects of antiarrhythmic drugs. Panagin helps to cope with the lack of potassium ions in the blood, which is associated with prolonged use of diuretic medications. Non-steroidal anti-inflammatory drugs, heparin, cyclosporine, increase the likelihood of hyperkalemia. When using general anesthetics, the inhibitory effect of the drug on the central nervous system increases.
Increased neuromuscular blockade can occur under the influence of decamethonium, suxamethonium and atracuronium. The use of astringents and coating agents reduces the absorption of trace elements in the stomach.
The drug improves the tolerability of antiarrhythmic and cardiotonic drugs.
Panangin forte 60 pcs. film-coated tablets
pharmachologic effect
Potassium and magnesium preparation.
Composition and release form Panangin forte 60 pcs. film-coated tablets
Tablets - 1 tablet:
- Active ingredients: potassium aspartate 316.00 mg (in the form of potassium aspartate hemihydrate 332.60 mg), magnesium aspartate 280.00 mg (in the form of magnesium aspartate tetrahydrate 350.00 mg);
- Excipients: corn starch 172.20 mg, talc 20.00 mg, magnesium stearate 8.00 mg, potato starch 6.60 mg, povidone KZO 6.60 mg, colloidal silicon dioxide 4.00 mg;
- Tablet shell: talc 7.30 mg, butyl methacrylate copolymer 6.00 mg, titanium dioxide (color index: CI 77891, E171) 5.30 mg, macrogol-6000 1.40 mg.
15 tablets in a blister made of PVC/PVDC and aluminum foil. 2, 4, 6 blisters along with instructions for use are placed in a cardboard box.
Description of the dosage form
Oval, biconvex, film-coated tablets, white or almost white, with a slightly glossy surface, engraved “A83” on one side, almost odorless. On a cross section it is white or almost white in color.
Directions for use and doses
Before use, you should consult your doctor.
Take orally, without chewing and with plenty of water.
Panangin Forte should be taken after meals, because... the acidic environment of the stomach reduces its effectiveness.
Recommended daily dose: 1 tablet 3 times a day. Maximum daily dose: 1 tablet 3 times a day.
Pharmacodynamics
The most important intracellular cations of potassium (K+) and magnesium (Mg++) play a key role in the functioning of numerous enzymes, in the formation of bonds between macromolecules and intracellular structures and in the mechanism of muscle contractility. The intra- and extracellular ratio of potassium, calcium, sodium and magnesium ions affects myocardial contractility. Endogenous aspartate acts as a conductor of ions: it has a high affinity for cells, due to the slight dissociation of its salts, ions in the form of complex compounds penetrate into the cell. Magnesium aspartate and potassium aspartate improve myocardial metabolism.
Lack of magnesium/potassium predisposes to the development of arterial hypertension, atherosclerosis of the coronary arteries, arrhythmias and metabolic changes in the myocardium.
Each tablet of the drug Panangin Forte contains 280 mg of magnesium aspartate and 316 mg of potassium aspartate, which is 2 times higher than the content of active ingredients in the drug Panangin, film-coated tablets. The daily dose of the drug Panangin Forte: 1 tablet 3 times a day, corresponds to the daily dose of the drug Panangin: 2 tablets 3 times a day. Taking a single dose of Panangin Forte in the form of one tablet makes treatment more convenient for the patient.
Pharmacokinetics
Potassium and magnesium aspartates are intensively absorbed in the intestine, mainly in the small intestine. Excreted by the kidneys.
Indications for use Panangin forte 60 pcs. film-coated tablets
To eliminate potassium and magnesium deficiency as part of combination therapy for various manifestations of coronary heart disease (including acute myocardial infarction); chronic heart failure; heart rhythm disturbances (including arrhythmias caused by an overdose of cardiac glycosides).
Contraindications
Hypersensitivity to any of the constituent components of the drug, acute and chronic renal failure, hyperkalemia, hypermagnesemia, Addison's disease, atrioventricular block I-III degree, shock (including cardiogenic) (blood pressure less than 90 mm Hg), metabolic disorders amino acids, myasthenia gravis, hemolysis, acute metabolic acidosis, dehydration state, age under 18 years (efficacy and safety have not been established). Pregnancy (especially in the first trimester of pregnancy) and the period of breastfeeding.
Application of Panangin forte 60 pcs. film-coated tablets during pregnancy and breastfeeding
Use is possible if the potential benefit to the mother outweighs the possible risk to the fetus.
Potassium and magnesium aspartate pass into breast milk. If it is necessary to take the drug during breastfeeding, breastfeeding should be stopped.
special instructions
Patients with diseases accompanied by hyperkalemia require special attention: regular monitoring of potassium levels in the blood plasma is necessary.
Overdose
The risk of symptoms of hyperkalemia and hypermagnesemia increases.
Symptoms of hyperkalemia: increased fatigue, myasthenia gravis, paresthesia, confusion, cardiac arrhythmia (bradycardia, atrioventricular block, arrhythmias, cardiac arrest).
Symptoms of hypermagnesemia: decreased neuromuscular excitability, nausea, vomiting, lethargy, decreased blood pressure.
With a sharp increase in the content of magnesium ions in the blood: inhibition of deep tendon reflexes, respiratory paralysis, coma.
Treatment: symptomatic therapy - intravenous administration of calcium chloride at a dose of 100 mg/min, if necessary - hemodialysis.
Side effects Panangin forte 60 pcs. film-coated tablets
Possible nausea, vomiting, diarrhea, discomfort or burning sensation in the epigastric region (in patients with anacid gastritis or cholecystitis), atrioventricular block, paradoxical reaction (increased number of extrasystoles), hyperkalemia (nausea, vomiting, diarrhea, paresthesia), hypermagnesemia (redness of the face , feeling of thirst, decreased blood pressure, hyporeflexia, respiratory depression, convulsions).
If any of the side effects listed become serious, or you notice side effects not listed in this leaflet, you should consult your doctor.
Drug interactions
Pharmacodynamic interaction
When used together with potassium-sparing diuretics (triamterene, spironolactone), beta-blockers, cyclosporine, heparin, angiotensin-converting enzyme (ACE) inhibitors, and non-steroidal anti-inflammatory drugs, the risk of developing hyperkalemia up to the development of arrhythmia and asystole increases. The simultaneous use of potassium supplements with glucocorticosteroids eliminates the hypokalemia caused by the latter. Potassium reduces the undesirable effects of cardiac glycosides. Panangin Forte enhances the negative dromo- and bathmotropic effects of antiarrhythmic drugs. Magnesium reduces the effects of neomycin, polymyxin B, tetracycline and streptomycin. Anesthetics increase the inhibitory effect of magnesium preparations on the central nervous system; when used simultaneously with atracuronium, decamethonium, succinyl chloride and suxamethonium, neuromuscular blockade may be enhanced. Calcitriol increases the content of magnesium in the blood plasma, calcium supplements reduce the effects of magnesium supplements.
Pharmacokinetic interaction
Medicines that have an astringent and enveloping effect reduce the absorption of magnesium aspartate and potassium aspartate in the gastrointestinal tract, therefore it is necessary to maintain a three-hour interval between oral administration of Panangin Forte with the above medications.
