Comparing Valocordin and Valoserdin | Determining the best

Expert: Abramova Tsilya

The drugs Valocordin and Valoserdin are analogues. However, the first one is already considered outdated and ineffective. We compared the features of the products to understand their key differences.

Compound

Valocordin was previously produced by the German company KREWEL MEUSELBACH GmbH, which currently synthesizes the chemical formula of the drug specifically for the post-Soviet countries.

In Western countries, Valocordin is considered an outdated drug, but in the territory of the former Soviet Union it has not lost its popularity to this day.

Valoserdin is a domestic analogue of Valocordin with an almost identical composition.

Valocordin is produced on the basis of the active ingredients - phenobarbital and ethyl bromizovalerianate (18.4 mg each) with the addition of mint and hop oils, ethanol and purified water.

Valoserdin contains the same active components. Instead of hop oil, oregano oil is added to the composition of the excipients. This slight difference does not affect the effect of the drug in any way.

Medicines are available in liquid form in bottles equipped with special droppers that allow you to accurately determine the dosage.

Therapeutic effect

The effect of the drug is influenced by its ingredients:

• Phenobarbital belongs to the toxic and potent substances from the group of barbiturates (a derivative of barbituric acid). It has hypnotic, antihyperbilirubinemic, anticonvulsant, antispasmodic and muscle relaxant effects through a non-selective depressant effect on the central nervous system.
• Ethyl bromizovalerianate (ethyl ester of alpha-bromoisovaleric acid), is a synthetic compound based on isovaleric acid (the active substance of valerian). Ethyl bromizovalerianate has the beneficial properties of valerian: sedative, hypnotic, antispasmodic - and provides them with medicinal properties.
• Ethanol dilates blood vessels, improves blood circulation and thins the blood. In addition, the ingredient plays the role of a solvent for the constituent drugs.
• Peppermint oil can improve sleep, calm the nervous system and increase stress resistance.
• Hops oil helps relax the nervous system and helps cope with insomnia.
• Oregano oil eliminates pain, helps relieve nervous tension, relieves anxiety, normalizes blood pressure, improves metabolism, and also stimulates blood circulation.

In many foreign countries, the use of barbiturate-based drugs is prohibited due to their negative impact on health.

The active ingredients Valocordin and Valoserdin lead to the following therapeutic effects:

• decreased excitation of the central nervous system;
• eliminating anxiety, feelings of worry;
• making it easier to fall asleep;
• improving heart function;
• lowering blood pressure;
• reflex vasodilation;
• relieving spasms of smooth muscles (both in internal organs and in blood vessels);
• slight relief of pain.

It is obvious that there are practically no differences between Valocordin and Valoserdin.

Nelfinavir

Nelfinavir is used in combination with other antiviral drugs to treat HIV. The study was carried out by Japanese scientists. According to the data obtained, the drug is able to block the reproduction of SARS-CoV-2. Virologists studied nine similar drugs and found that nelfinavir is effective even in small doses. Therefore, it is recommended to include it in the list of potentially effective drugs for the treatment of COVID-19.

What to do while there is no vaccine

• wear medical masks when visiting public places;
• on the street and in crowded places, maintain a distance of at least 1.5 m from others;
• avoid contact with people who have been exposed to the virus;
• stay at home if possible;
• wash your hands thoroughly with soap;
• use a disinfectant with an alcohol content of at least 60%;
• do not touch your face;
• monitor hygiene in the house.

Indications

Interestingly, neither Valocordin nor Valoserdin are classified as “heart” drugs. According to the modern classification, they are sedatives.

However, due to the antispasmodic effect of the drugs, the coronary vessels expand, blood flow to the heart increases and pain is eliminated.

Getting rid of heart pain with the help of Valocordin or Valoserdin is not a way out of the situation. Need to see a doctor

The instructions for medications list their indications in detail.

Valocordin and Valoserdin help get rid of:

• difficulty falling asleep;
• pain in the left half of the chest;
• increased heart rate due to accelerated sinus rhythm;
• neurotic states (anxiety and irritability);
• hypochondriacal syndrome (excessive, groundless concern for one’s health);
• instability of the autonomic nervous system, i.e. failures in the processes for which it is responsible;
• high blood pressure (in the initial stages);
• muscle spasms of the gastrointestinal tract (intestinal and biliary colic).

It should be borne in mind that monotherapy with these drugs is not recommended for increased blood pressure. The vasodilating and sedative effects of the drugs help eliminate mild arterial hypertension, but the drugs are not intended to get rid of the disease.

It must be remembered that medications only eliminate the unwanted symptoms of diseases and in no way relieve them. The exposure time of drugs is limited by the period of stay of their active components in the patient’s body.

Interestingly, Valocordin is widely used in folk medicine to treat herpes. Systematic treatment of rashes with the drug leads to their speedy healing. Considering the almost identical drugs, we can conclude that Valoserdin can also be used for these purposes.

Remdesivir

Remdesivir is used to treat Ebola fever. Canadian scientists from the University of Alberta have found that the drug blocks the reproduction of coronavirus. Studies have proven the effectiveness of the antiviral agent in the treatment of MERS respiratory syndrome and SARS-CoV, the RNA structure of which is similar to coronavirus. Virologists obtained identical results in the case of SARS-CoV-2, which causes COVID-19, and concluded that remdesivir could be used for treatment. The New England Journal of Medicine also published the results of a study in which the use of the drug improved the condition of 68% of patients. Japanese Prime Minister Shinzo Abe said in parliament on April 28 that he plans to authorize the use of remdesevir to treat COVID-19. In the United States, the drug was successfully tested, and on May 2, the Department of Sanitary Inspection issued an emergency permit for its use.

Contraindications, undesirable effects and overdose symptoms

Valocordin and Valoserdin also have no contraindications and should not be used:

• In case of hypersensitivity to drug ingredients.
• Pregnant women and during lactation to avoid harm to the health of the expectant mother and child. By the way, sometimes it is possible for pregnant women to take medications only after a specialist has analyzed the relationship between the need to use medications and the risk of undesirable consequences.
• Until reaching adulthood. This is due to the specificity of the active ingredients of the drugs and possible addiction. Prescription of drugs for children is possible in an interesting dosage - 1 drop per year of life, regardless of age and body weight.
• With pathological changes in the liver and kidneys.
• With alcohol abuse. Drinking alcoholic beverages within 4 days after using phenobarbital-based drugs increases the risk of: increased heart rate; sudden onset of hypotension; speech retardation; ataxia; dizziness; spasms of the respiratory tract; drowsiness; disorders of consciousness; disruptions in the gastrointestinal tract.

Valoserdin and Valocordin are incompatible with alcohol

Coma cannot be ruled out.

Alcohol in combination with phenobarbital increases the negative effect on the liver, the removal of alcoholic beverages and drug components from the body becomes slower.

The combination of drugs and alcohol can have a stimulating effect on the nervous system or, conversely, depress it.

The combined use of Valocordin or Valoserdin with sedatives can cause an unpredictable enhanced effect and disruptions in the nervous system.

The combination of Valocordin or Valoserdin with drugs based on methotrexate is fraught with poisoning of the body.

Side effects of drugs that occur in rare cases include the following:

• drowsiness;
• slight dizziness.

Using medications for a long time can lead to chronic bromism (bromine poisoning), which is characterized by: rhinitis, deteriorated emotional state, decreased appetite, conjunctivitis, impaired coordination of movements, rashes on the skin.

Overdose can contribute to:

• excessive drowsiness and dizziness;
• various psychomotor disorders;
• tachycardia;
• difficulty breathing;
• critical decrease in blood pressure;
• vascular collapse;
• comatose state.

At the first signs of an overdose, you should stop using the medication, rinse your stomach, and consult a doctor to eliminate unwanted manifestations. Hospitalization of the patient is not excluded.

Danger

The popularity of drugs based on phenobarbital is due to their low price.

However, phenobarbital is extremely toxic. It is with the use of this substance that the death penalty is carried out in some states.

The active ingredient of Valocordin and Valoserdin, phenobarbital, is recognized in many countries as a narcotic substance and is subject to an import ban.

This representative of barbiturates promotes:

• weakening of cognitive abilities, i.e. the degree of perception of knowledge and information with their subsequent processing;
• aggravation of a person’s condition with existing mental disorders;
• addiction to drugs produced on its basis, which causes the risk of overdose;
• acceleration of metabolism, which leads to a decrease in the effectiveness of other drugs;
• untimely detection and treatment of cardiac pathologies due to the ability of phenobarbital to improve the patient’s condition without directly eliminating the pathology.

The effectiveness of phenobarbital is questionable. The substance eliminates the external manifestations of cardiovascular diseases, but does not eliminate them. In addition, its hypnotic effect is not too high.

The second active ingredient of Valocordin and Valoserdin, ethyl bromizovalerianate, can cause bromine poisoning with the following symptoms:

• weakness;
• pain of unknown origin;
• allergic phenomena;
• bronchitis;
• pulmonary edema;
• runny nose;
• shortness of breath, etc.

All manifestations of poisoning are similar to the appearance of numerous diseases.

In addition, a derivative for the production of ethyl bromizovalerianate is a toxic product of the retification of bodyagi alcohol containing fusel oil and other toxic substances.

What we know about COVID-19

COVID-19 is an infectious disease caused by the coronavirus SARS-CoV-2. Discovered in China at the end of 2021, by May 15 it had infected 4.4 million people worldwide. Most of those with symptoms complain of fever, cough and difficulty breathing. Special medications and vaccines against COVID-19 have not yet been developed. However, virologist and head of the MIPT genome engineering laboratory Pavel Volchkov said that the first effective cure for coronavirus infection may appear in the fall.

In general, the Ministry of Health recommends the use of six drugs to treat coronavirus. these are favipiravir, remdesivir, umifenovir, hydroxychloroquine, azithromycin and interferon alfa.

Analogs

There are many medications that can replace the above drugs.

Corvalol is a drug identical to Valoserdin and Valocordin

Corvalol is a domestic medical product that is produced from the same ingredients as Valocordin. It has the same effect and has the same contraindications and side effects. The only difference is the release form. Corvalol is available not only in drops, but also in tablets.

Relaxil - produced in Ukraine in the form of capsules containing extracts of valerian, lemon balm and mint. Contains natural ingredients and is well tolerated by patients.

Recommended for:

• nervous overstrain and excessive excitement;
• mild forms of neurasthenia and neurosis;
• feelings of irritability, anxiety and fear;
• mild form of insomnia;
• headaches due to nervous tension;
• neurocirculatory dystonia accompanied by tachycardia;
• hypertension in the initial stages.

Notta is an Austrian homeopathic medicine available in the form of drops and tablets. Eliminates insomnia, increased excitability and other minor nervous disorders. Contains zinc valerianate, chamomile, phosphorus, coffee tree extract and seed oats. Has a minimum of side effects.

Kaviton is a Hungarian drug with a wide spectrum of action based on the active component vinpocetine. Available in tablets and in the form of a concentrate for infusion. Effective for neurological and mental disorders. It is used not only in neurology, but also in ophthalmology and otorhinolaryngology.

Ivermectin

Australian scientists from Monash University and the Royal Melbourne Hospital have discovered an antiparasitic agent that virtually destroys the SARS-CoV-2 virus within 48 hours, reducing its presence by 99%. According to researchers, the use of ivermectin will help avoid severe complications of COVID-19, as well as prevent the spread of the virus. During the experiments, ivermectin was added to cells infected with SARS-CoV-2. After 24 hours, the proportion of viral RNAs decreased by 93%, and after 48 hours, the presence of the virus decreased by 99%.

A single treatment with ivermectin can reduce the virus by 5 thousand times in 48 hours, scientists say. The drug is approved by WHO.

Valoserdin and Valocordin - the difference

Despite the identity of Valoserdin and Valocordin, a minimal difference still exists:

• drugs have different manufacturers. Valoserdin is produced in Russia, Valocordin - in Germany;
• Valocordin contains hop oil; in Valocordin this component is replaced by oregano oil;
• the domestic drug is more expensive than its German counterpart;
• Valocordin began to be produced much earlier than Valoserdin.

The choice of medication depends not only on the patient, but also on the attending physician. Before starting treatment, you should consult with a specialist who, depending on your health condition, will select the most optimal drug.

APN01

The Austrian biotechnology company APEIRON Biologics AG has begun clinical trials of the drug APN01, which was developed in the early 2000s. Scientists have discovered that the ACE2 protein, which is part of it, suppresses infections caused by viruses of the SARS group. It also helps protect the lungs during respiratory failure.

The authorities of Austria, Germany and Denmark agreed to conduct clinical trials of the drug. During the study, 200 patients with COVID-19 will receive APN01. Then virologists will evaluate the effect of the drug, and also analyze its effectiveness and safety for patients who require artificial ventilation.