Comparison of the effectiveness of Concor and Bisoprolol
Concor is more effective than Bisoprolol - this means that the ability of the medicinal substance to provide the maximum possible effect is different.
For example, if the therapeutic effect of Concor is more pronounced, then with Bisoprolol it is impossible to achieve this effect even in large doses.
Also, the speed of therapy is an indicator of the speed of the therapeutic action; Concor and Bisoprolol are also different, as is bioavailability - the amount of a drug substance reaching the place of its action in the body. The higher the bioavailability, the less it will be lost during absorption and use by the body.
What is the difference
Concor is produced by the German pharmaceutical company Merck KGaA, and Bisoprolol is a Russian-made generic that is produced by several domestic enterprises, which is not reflected in its cost. Among the producers of Bisoprolol are also Indian, Ukrainian and Belarusian pharmaceutical companies.
These two drugs differ in composition:
- The amount of active component.
- Various auxiliary components.
- The generic may contain the monohydrate form of lactose.
Comparison of the safety of Concor and Bisoprolol
The safety of a drug includes many factors.
At the same time, in Concor it is quite similar to Bisoprolol. It is important where the drug is metabolized: drugs are excreted from the body either unchanged or in the form of products of their biochemical transformations. Metabolism occurs spontaneously, but most often involves major organs such as the liver, kidneys, lungs, skin, brain and others. When assessing the metabolism of Concor, as well as Bisoprolol, we look at which organ is the metabolizing organ and how critical the effect on it is.
The risk-benefit ratio is when the prescription of a drug is undesirable, but justified under certain conditions and circumstances, with the obligatory observance of caution in use. At the same time, Concor does not have any risks when used, just like Bisoprolol.
Also, when calculating safety, it is taken into account whether only allergic reactions occur or possible dysfunction of the main organs. In other matters, as well as the reversibility of the consequences of using Concor and Bisoprolol.
Bisoprolol Canon
Combinations not recommended
Class I antiarrhythmic drugs
Class I antiarrhythmic drugs (for example, quinidine, disopyramide, lidocaine, phenytoin, flecainide, propafenone), when used simultaneously with bisoprolol, can slow down atrioventricular conduction and reduce cardiac contractility.
Verapamil and diltiazem
Non-dihydropyridine slow calcium channel blockers (SCBCs), such as verapamil and, to a lesser extent, diltiazem, when used simultaneously with bisoprolol, can lead to a decrease in myocardial contractility and impaired atrioventricular conduction, cardiac arrest and heart failure. In particular, intravenous administration of verapamil to patients taking beta-blockers can lead to severe arterial hypotension and atrioventricular block.
Centrally acting antihypertensives
The simultaneous use of bisoprolol with centrally acting antihypertensive drugs (such as clonidine, methyldopa, moxonidine, rilmenidine) can lead to a worsening of heart failure due to a decrease in central sympathetic tone (decreased heart rate, decreased cardiac output, peripheral vasodilation).
Abrupt discontinuation of centrally acting antihypertensive drugs, especially before discontinuation of beta-blockers, may increase the risk of developing “rebound” arterial hypertension (slow calcium channel syndrome (SCCS) - dihydropyridine derivatives
BMCC - dihydropyridine derivatives (for example, nifedipine, felodipine, amlodipine), when used simultaneously with bisoprolol, may increase the risk of developing arterial hypotension. In patients with CHF, the risk of further deterioration of cardiac contractile function cannot be excluded.
Medicines that lower blood pressure
Antihypertensive drugs (diuretics, clonidine, etc.) as well as other drugs with a possible antihypertensive effect (for example, tricyclic antidepressants, barbiturates, phenothiazines) can enhance the antihypertensive effect of bisoprolol and lead to an excessive decrease in blood pressure.
Beta blockers for topical use
The effect of beta-blockers for topical use (for example, eye drops for the treatment of glaucoma) may enhance the systemic effects of bisoprolol (lowering blood pressure, lowering heart rate).
Cholinomimetics
Cholinomimetics (parasympathomimetics), when used simultaneously with bisoprolol, may increase atrioventricular conduction disturbances and increase the risk of developing bradycardia.
Hypoglycemic drugs
The hypoglycemic effect of insulin or oral hypoglycemic agents may be enhanced. Signs of hypoglycemia - in particular tachycardia - may be masked or suppressed. Such interactions are more likely when using non-selective beta-blockers.
General anesthesia products
Inhalational anesthetics may increase the risk of cardiodepressive effects. There is a decrease in reflex tachycardia, an increase in the risk of bradyarrhythmias and severe arterial hypotension.
Cardiac glycosides
Cardiac glycosides, when used simultaneously with bisoprolol, can lead to an increase in impulse conduction time, and thus to the development of bradycardia. Cardiac glycosides increase the risk of developing atrioventricular block, cardiac arrest and heart failure.
Nonsteroidal anti-inflammatory drugs (NSAIDs)
NSAIDs may reduce the antihypertensive effect of bisoprolol (through sodium ion retention and blockade of prostaglandin synthesis by the kidneys).
Sympathomimetics
Concomitant use of bisoprolol with beta-agonists (such as isoprenaline or dobutamine) may lead to a decrease in the effect of both drugs. Concomitant use of bisoprolol with beta- and alpha-adrenergic agonists (such as epinephrine [adrenaline]) may enhance the vasoconstrictor effects resulting from alpha-adrenergic stimulation and lead to the development of hypertension or worsening intermittent claudication. Such interactions are more likely when using non-selective beta-blockers.
Cases of the development of severe arterial hypertension have been described with the simultaneous use of bsta-blockers with alpha-adrenergic agonists, including drugs for topical use (for example, decongestants in the form of nasal drops).
Combinations to Consider
Mefloquine
Mefloquine, when used simultaneously with bisoprolol, may increase the risk of bradycardia.
Monoamine oxidase inhibitors (MAO)
MAO inhibitors (except MAO B inhibitors) may enhance the antihypertensive effect of beta-blockers. Concomitant use may also lead to the development of a hypertensive crisis. The break in treatment between the discontinuation of MAO inhibitors and the prescription of bisoprolol should be at least 14 days.
Ergot alkaloids
Non-hydrogenated ergot alkaloids increase the risk of developing peripheral circulatory disorders. Ergotamine increases the risk of developing peripheral circulatory disorders.
Pharmacokinetic interactions
Rifampicin increases metabolic clearance and shortens the half-life of bisoprolol. Usually no dose adjustment is required. Caution should be exercised when using bisoprolol simultaneously with inducers of isoenzymes of microsomal liver oxidation.
It is possible to increase the concentration of bisoprolol in the blood plasma when used simultaneously with inhibitors of the CYP3A4 isoenzyme and reduce it when used simultaneously with inducers of CYP3A4. Bisoprolol may increase the plasma concentration of drugs metabolized with the participation of the CYP3A4 isoenzyme and, possibly, CYP2D6.
Pharmacokinetic studies did not reveal interactions of bisoprolol with thiazide diuretics, digoxin and cimetidine. Bisoprolol does not affect prothrombin time in patients receiving a stable dose of warfarin.
Comparison of addiction between Concor and Bisoprolol
Like safety, addiction also involves many factors that must be considered when evaluating a drug.
So, the totality of the values of such parameters as “o syndrome” in Concor is quite similar to the similar values in Bisoprolol. Withdrawal syndrome is a pathological condition that occurs after the cessation of intake of addictive or dependent substances into the body. And resistance is understood as initial immunity to a drug; in this it differs from addiction, when immunity to a drug develops over a certain period of time. The presence of resistance can only be stated if an attempt has been made to increase the dose of the drug to the maximum possible. At the same time, Concor has a fairly low incidence of “syndrome”, just like Bisoprolol.
Side effects
Both drugs may cause similar side effects. The degree of their intensity depends on the individual characteristics of the body and the type of disease present.
Quite often, increased fatigue, dizziness and headache may occur. Sometimes depression manifests itself, and insomnia may occur. And those who wear contact lenses should take into account that taking medications may reduce tearing. The manifestation of bronchospasms in patients diagnosed with bronchial asthma is infrequent, and allergic rhinitis is even less common.
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Those who have problems with the cardiovascular system and blood pressure should take medications most carefully and cautiously. It is necessary to regularly measure it and monitor the pulse rate, since side effects such as bradycardia, decreased blood pressure, a feeling of coldness in the extremities or numbness, and some others are common.
If at least one of them occurs, you should immediately contact your doctor so that he can determine the causes and adjust the dose of the drug or stop it.
There are infrequent cases of side effects from the digestive system in the form of nausea, vomiting, diarrhea or constipation, and cases of hepatitis are rare.
There are very few manifestations of negative reactions that are shown by the musculoskeletal system or the skin. But you need to know that, in addition to muscle weakness, sometimes there are cramps, and the symptoms of psoriasis may also worsen or a psoriasis-like rash may appear.
Rarely, there are manifestations of disturbances in the functioning of the reproductive system, which are expressed in impaired potency.
In addition to regular monitoring of blood pressure and pulse, you need to periodically take blood tests to determine the level of triglycerides, the concentration of which may increase when taking Concor or Bisoprolol. It is necessary to monitor the activity of liver transaminases in the blood.
All side effects are indicated in the instructions that are included in the drug packaging.
Comparison of side effects of Concor and Bisoprolol
Side effects or adverse events are any adverse medical event that occurs in a subject after administration of a drug.
Concor's side effects are almost the same as Bisoprolol's. They both have few side effects. This implies that the frequency of their occurrence is low, that is, the indicator of how many cases of an undesirable effect of treatment are possible and registered is low. The undesirable effect on the body, the strength of influence and the toxic effect of Concor are similar to Bisoprolol: how quickly the body recovers after taking it and whether it recovers at all.
How to take Bisoprolol and Concor
A course of treatment with Bisoprolol or Concor tablets is prescribed according to individual indications. It all depends on the diagnosis, general health and age of the patient, his physiological indicators. The dose is one 5-milligram tablet. But it may need to be increased or decreased depending on the body's response.
The tablets are equally effective before or after meals.
You need to drink them with a small amount of water, without chewing or grinding them into powder. Drugs are eliminated from the body by balanced clearance, that is, by both the liver and kidneys.
An important advantage of the drugs is their gentle effect on the body, so Concor or Bisoprolol tablets can be prescribed to elderly patients, but taking into account everything that has already been said. Acting gently, these drugs have a powerful therapeutic effect, causing minimal damage to the body.
If you have chosen one of the analogues of Concor or Bisoprolol, be sure to discuss the issue with your doctor. This is important, since there are differences in the time of taking the drug, the speed of onset of the therapeutic response, the daily dose, and the side effects caused.
Taking any of these drugs is incompatible with alcohol, no matter the amount of alcohol it contains.
Quite often, when taking Concor, you may experience increased fatigue, dizziness and headache.
Comparison of ease of use of Concor and Bisoprolol
This includes dose selection taking into account various conditions and frequency of doses. At the same time, it is important not to forget about the release form of the drug; it is also important to take it into account when making an assessment.
The ease of use of Concor is approximately the same as Bisoprolol. However, they are not convenient enough to use.
The drug ratings were compiled by experienced pharmacists who studied international research. The report is generated automatically.
Last update date: 2020-12-13 10:32:35
Reviews from doctors
Svetlova I. V., cardiologist, Novosibirsk
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Bisoprolol is a high-quality generic of Concor. The drug is good, it is important that it has a long period of action. The drug is well tolerated, has a quick effect, and works gently.
Mitin P. G., cardiologist, Rostov-on-Don
Concor is a German-made drug; it belongs to the original pharmaceutical products. It is effective and safe. As for Bisoprolol, the quality is largely influenced by the manufacturer.
Vernigorov B.S., cardiologist, St. Petersburg
Concor is an original drug, so I boldly call it the standard of therapeutic effectiveness and safety. Generic Bisoprolol is only approaching it. Concor is well tolerated, with few side effects typical of beta blockers. I believe that in its class of drugs it is one of the safest.
Patient reviews
Sofia, 35 years old, Saratov
I took Bisoprolol and began to feel weak, nausea and even intestinal upset. Therefore, I returned to Concor again, although it is more expensive.
Evgeniy, 56 years old, Sevastopol
I took Concor, then I found out that Bisoprolol is several times cheaper, and is a complete analogue. I switched to taking Bisoprolol, and so far there is no reason to regret it: my blood pressure is normal, I also cope with tachycardia and I don’t observe any side effects.
Kristina, 43 years old, Petrozavodsk
If, like me, you have both blood pressure and ischemia, then Concor is what you need. I don't know any better medicine. I buy a package for 300 rubles. I take a heart-shaped tablet once a day. The doctor prescribed this because the dosage is different.
